ArticleJournal of agricultural and food chemistry2015
Structural and Functional Characterization of the Hazelnut Allergen Cor a 8.
Article in Journal of agricultural and food chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Lipid Transfer Protein Allergens: A Comprehensive Overview of Current Knowledge.International journal of molecular sciences · 2026Review
- The Role of Nut Sensitization in Pru p 3-Sensitized Patients: A XGBoost and Generalized Linear Model Application.International journal of molecular sciences · 2026Article
- Calcium-binding proteins as allergens.Frontiers in allergy · 2026Review
- Hazelnut allergome overview and Cor a gRNAs identification.BMC plant biology · 2025Article
- Role of Small Molecule Ligands in IgE-Mediated Allergy.Current allergy and asthma reports · 2023Review
- The structural characterization and bioactivity assessment of nonspecific lipid transfer protein 1 (nsLTP1) from caraway (Carum carvi) seeds.BMC complementary medicine and therapies · 2023Article
- Food Allergens of Plant Origin.Foods (Basel, Switzerland) · 2023Review
- Natural History of Hazelnut Allergy and Current Approach to Its Diagnosis and Treatment.Children (Basel, Switzerland) · 2023Review
- Factors and co-factors influencing clinical manifestations in nsLTPs allergy: between the good and the bad.Frontiers in allergy · 2023Review
- INFOGEST Digestion Assay of Raw and Roasted Hazelnuts and Its Impact on Allergens and Their IgE Binding Activity.Foods (Basel, Switzerland) · 2022Article
- IgE epitopes of Ara h 9, Jug r 3, and Pru p 3 in peanut-allergic individuals from Spain and the US.Frontiers in allergy · 2022Article
- Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.Clinical and translational allergy · 2021Article
- Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens.Journal of visualized experiments : JoVE · 2021Article
- Structural Characterization of Act c 10.0101 and Pun g 1.0101-Allergens from the Non-Specific Lipid Transfer Protein Family.Molecules (Basel, Switzerland) · 2021Article
- Structural characterization and in vitro lipid binding studies of non-specific lipid transfer protein 1 (nsLTP1) from fennel (Foeniculum vulgare) seeds.Scientific reports · 2020Article
- Impact of lipid binding on the tertiary structure and allergenic potential of Jug r 3, the non-specific lipid transfer protein from walnut.Scientific reports · 2019Article
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- High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti.Acta crystallographica. Section F, Structural biology communications · 2017Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonspecific lipid transfer proteins (nsLTPs) are basic proteins, stabilized by four disulfide bonds, and are expressed throughout the plant kingdom. These proteins are also known as important allergens in fruits and tree nuts. In this study, the nsLTP from hazelnuts, Cor a 8, was purified and its crystal structure determined. The protein is stable at low pH and refolds after thermal denaturation. Molecular dynamics simulations were used to provide an insight into conformational changes of Cor a 8 upon ligand binding. When known epitope areas from Pru p 3 were compared to those of Cor a 8, differences were obvious, which may contribute to limited cross-reactivity between peach and hazelnut allergens. Differences in epitope regions may contribute to limited cross-reactivity between Cor a 8 and nsLTPs from other plant sources. The structure of Cor a 8 represents the first resolved structure of a hazelnut allergen.
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