ArticleOsteoarthritis and cartilage2016
Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage.
Article in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Integrative multi-omics analysis reveals gut microbiota-derived metabolites and immune regulatory pathways in osteoarthritis pathogenesis.Journal of orthopaedic surgery and research · 2026Article
- Energy crisis and cartilage collapse: metabolic reprogramming of chondrocytes in osteoarthritis.Frontiers in immunology · 2026Review
- Thick or Thin? Implications of Cartilage Architecture for Osteoarthritis Risk in Sedentary Lifestyles.Biomedicines · 2025Review
- A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.Materials today. Bio · 2024Article
- Chondrocytic and pharmacokinetic properties of Phlpp inhibitors.Osteoarthritis and cartilage open · 2021Article
- Pathomechanisms of Posttraumatic Osteoarthritis: Chondrocyte Behavior and Fate in a Precarious Environment.International journal of molecular sciences · 2020Review
- Analysis of "old" proteins unmasks dynamic gradient of cartilage turnover in human limbs.Science advances · 2019Article
- Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Post-traumatic osteoarthritis of the ankle: A distinct clinical entity requiring new research approaches.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Review
- Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing.Rheumatology (Oxford, England) · 2017Article
- Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.Osteoarthritis and cartilage · 2015Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe investigated tissue turnover in healthy and osteoarthritic cartilage. We challenge long held views that osteoarthritis (OA) is dominated by a similar turnover process in all joints and present evidence that hip and knee cartilage respond very differently to OA.
methodsd- and l-Aspartate (Asp) were quantified for whole cartilage, collagen and non-collagenous components of cartilage obtained at the time of joint replacement. We computed the Asp racemization ratio (Asp-RR = d/d + l Asp), reflecting the proportion of old to total protein, for each component.
resultsCompared with hip OA, knee OA collagen fibrils (P < 0.0001), collagen (P = 0.007), and non-collagenous proteins (P = 0.0003) had significantly lower age-adjusted mean Asp-RRs consistent with elevated protein synthesis in knee OA. Knee OA collagen had a mean hydroxyproline/proline (H/P) ratio of 1.2 consistent with the presence of type III collagen whereas hip OA collagen had a mean H/P ratio of 0.99 consistent with type II collagen. Based on Asp-RR, the relative age was significantly different in knee and hip OA (P < 0.0005); on average OA knees were estimated to be 30 yrs 'younger', and OA hips 10 yrs 'older' than non-OA.
conclusionsThe metabolic response to OA was strikingly different by joint site. Knee OA cartilage evinced an anabolic response that appeared to be absent in hip OA cartilage. These results challenge the long held view that OA cartilage is capable of only minimal repair and that collagen loss is irreversible.
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