ArticleHuman brain mapping2015
Patient specific hemodynamic response functions associated with interictal discharges recorded via simultaneous intracranial EEG-fMRI.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Characterization of resting functional MRI activity alterations across epileptic foci and networks.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Simultaneous electroencephalography-functional magnetic resonance imaging for assessment of human brain function.Frontiers in systems neuroscience · 2022Review
- Clinical safety of intracranial EEG electrodes in MRI at 1.5 T and 3 T: a single-center experience and literature review.Neuroradiology · 2021Review
- Identification of Negative BOLD Responses in Epilepsy Using Windkessel Models.Frontiers in neurology · 2021Article
- Localizing Epileptic Foci Using Simultaneous EEG-fMRI Recording: Template Component Cross-Correlation.Frontiers in neurology · 2021Article
- Dynamic oxygen changes during status epilepticus and subsequent endogenous kindling.Epilepsia · 2020Article
- Temperature Measurements in the Vicinity of Human Intracranial EEG Electrodes Exposed to Body-Coil RF for MRI at 1.5T.Frontiers in neuroscience · 2020Article
- The spike onset zone: The region where epileptic spikes start and from where they propagate.Neurology · 2018Article
- Identification of neurovascular changes associated with cerebral amyloid angiopathy from subject-specific hemodynamic response functions.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- A study of the electro-haemodynamic coupling using simultaneously acquired intracranial EEG and fMRI data in humans.NeuroImage · 2016Article
- Complex discharge-affecting networks in juvenile myoclonic epilepsy: A simultaneous EEG-fMRI study.Human brain mapping · 2016Article
- Influence of BOLD Contributions to Diffusion fMRI Activation of the Visual Cortex.Frontiers in neuroscience · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Simultaneous collection of scalp EEG and fMRI has become an important tool for studying the hemodynamic changes associated with interictal epileptiform discharges (IEDs) in persons with epilepsy, and has become a standard presurgical assessment tool in some centres. We previously demonstrated that performing EEG-fMRI using intracranial electrodes (iEEG-fMRI) is of low risk to patients in our research centre, and offers unique insight into BOLD signal changes associated with IEDs recorded from very discrete sources. However, it is unknown whether the BOLD response corresponding to IEDs recorded by iEEG-fMRI follows the canonical hemodynamic response. We therefore scanned 11 presurgical epilepsy patients using iEEG-fMRI, and assessed the hemodynamic response associated with individual IEDs using two methods: assessment of BOLD signal changes associated with isolated IEDs at the location of the active intracranial electrode, and by estimating subject-specific impulse response functions to isolated IEDs. We found that the hemodynamic response associated with the intracranially recorded discharges varied by patient and by spike location. The observed shape and timing differences also deviated from the canonical hemodynamic response function traditionally used in many fMRI experiments. It is recommended that future iEEG-fMRI studies of IEDs use a flexible hemodynamic response model when performing parametric tests to accurately characterize these data.
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