ReviewJournal of immunology research2015
The Bidirectional Relationship between Sleep and Immunity against Infections.
Review in Journal of immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05148858 (Study the Patterns of Sleep Disturbance and Quality of Life During Corona Virus Disease 19), which is not on this map. Cited by 105 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study the Patterns of Sleep Disturbance and Quality of Life During Corona Virus Disease 19 (COVID 19) Pandemic in Upper Egypt
Who cites it
105 citing papers in PubMed, 4 syntheses or guidelines pooled it, 232 citations in OpenAlex.
- Association between periodontal disease and non-apnea sleep disorder: a systematic review.Clinical oral investigations · 2020Pooled it
- Association between maternal sleep duration and quality, and the risk of preterm birth: a systematic review and meta-analysis of observational studies.BMC pregnancy and childbirth · 2020Pooled it
- Sleep Disturbance after Hospitalization and Critical Illness: A Systematic Review.Annals of the American Thoracic Society · 2017Pooled it
- Coronavirus disease 2019 (COVID-19) and cardiovascular risk: A meta-analysis.Progress in cardiovascular diseasesPooled it
- A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study (MAVRICS).Human vaccines & immunotherapeutics · 2024Trial
- Bifidobacterium longum 1714 improves sleep quality and aspects of well-being in healthy adults: a randomized, double-blind, placebo-controlled clinical trial.Scientific reports · 2024Trial
- Inflammatory exposures in early pregnancy and multidimensional sleep in late pregnancy: a prospective population-based study.Brain, behavior, & immunity - health · 2026Article
- Subjective menopausal hot flashes in sleep disturbance: does the timing of hot flashes matter?Menopause (New York, N.Y.) · 2026Article
- Mendelian Randomization Research Examining the Effects of Insomnia on Herpes Zoster and Postherpetic Neuralgia.Pain research & management · 2026Article
- Article
- SARS-CoV-2 infection and sleep health in Military Health System beneficiaries.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Article
- Sleep Quality Impacts Training Responses and Performance in Elite Swimmers.European journal of sport science · 2025Article
- IL-1b and TNF-a-driven sleep alterations: Neuroimmune mechanisms and behavioral implications.Brain, behavior, & immunity - health · 2025Review
- Epidemiology and Treatment Outcomes of Pulmonary Tuberculosis in Dazu District, Chongqing, China, 2005-2024: Surveillance Study.JMIR public health and surveillance · 2025Article
- Disruption of circadian rhythms and behavior in Drosophila melanogaster induced by Epstein-Barr virus: insights into viral infections and host physiology.Behavioral and brain functions : BBF · 2025Article
- Healthy sleep patterns and risk of hospitalization for infection: a large community-based cohort study.Translational psychiatry · 2025Article
- Long-term Effects of COVID-19 on Sleep PatternsThoracic research and practice · 2025Article
- The Role of Essential Oils on Sleep Quality and Other Sleep-related Issues: Evidence from Clinical Trials.Mini reviews in medicinal chemistry · 2025Review
- From infected to recovered: the mediating role of sleep quality between self-compassion, social support and COVID-19 psychosomatic symptoms.BMC public health · 2024Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is considered an important modulator of the immune response. Thus, a lack of sleep can weaken immunity, increasing organism susceptibility to infection. For instance, shorter sleep durations are associated with a rise in suffering from the common cold. The function of sleep in altering immune responses must be determined to understand how sleep deprivation increases the susceptibility to viral, bacterial, and parasitic infections. There are several explanations for greater susceptibility to infections after reduced sleep, such as impaired mitogenic proliferation of lymphocytes, decreased HLA-DR expression, the upregulation of CD14+, and variations in CD4+ and CD8+ T lymphocytes, which have been observed during partial sleep deprivation. Also, steroid hormones, in addition to regulating sexual behavior, influence sleep. Thus, we hypothesize that sleep and the immune-endocrine system have a bidirectional relationship in governing various physiological processes, including immunity to infections. This review discusses the evidence on the bidirectional effects of the immune response against viral, bacterial, and parasitic infections on sleep patterns and how the lack of sleep affects the immune response against such agents. Because sleep is essential in the maintenance of homeostasis, these situations must be adapted to elicit changes in sleep patterns and other physiological parameters during the immune response to infections to which the organism is continuously exposed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.