ArticleBiomedical optics express2015
Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Optical Imaging of Cilia in the Head and Neck.Journal of clinical medicine · 2025Review
- Second order and transverse flow visualization through three-dimensional particle image velocimetry in millimetric ducts.Experimental thermal and fluid science · 2024Article
- Three-dimensional particle streak velocimetry based on optical coherence tomography for assessing preimplantation embryo movement in mouse oviduct in vivo.Biomedical optics express · 2024Article
- Article
- Corneal biomechanics: Measurement and structural correlations.Experimental eye research · 2021Review
- Gaussian process post-processing for particle tracking velocimetry.Biomedical optics express · 2019Article
- Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus.Scientific reports · 2019Article
- Article
- Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography.Scientific reports · 2017Article
- Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography.Lasers in surgery and medicine · 2017Article
- Ultrahigh-speed, phase-sensitive full-field interferometric confocal microscopy for quantitative microscale physiology.Biomedical optics express · 2016Article
- Erratum: Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows: erratum.Biomedical optics express · 2016Article
- Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows.Biomedical optics express · 2016Article
- Improved velocimetry in optical coherence tomography using Bayesian analysis.Biomedical optics express · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Microscale quantification of cilia-driven fluid flow is an emerging area in medical physiology, including pulmonary and central nervous system physiology. Cilia-driven fluid flow is most completely described by a three-dimensional, three-component (3D3C) vector field. Here, we generate 3D3C velocimetry measurements by synthesizing higher dimensional data from lower dimensional measurements obtained using two separate optical coherence tomography (OCT)-based approaches: digital particle image velocimetry (DPIV) and dynamic light scattering (DLS)-OCT. Building on previous work, we first demonstrate directional DLS-OCT for 1D2C velocimetry measurements in the sub-1 mm/s regime (sub-2.5 inch/minute regime) of cilia-driven fluid flow in Xenopus epithelium, an important animal model of the ciliated respiratory tract. We then extend our analysis toward 3D3C measurements in Xenopus using both DLS-OCT and DPIV. We demonstrate the use of DPIV-based approaches towards flow imaging of Xenopus cerebrospinal fluid and mouse trachea, two other important ciliary systems. Both of these flows typically fall in the sub-100 μm/s regime (sub-0.25 inch/minute regime). Lastly, we develop a framework for optimizing the signal-to-noise ratio of 3D3C flow velocity measurements synthesized from 2D2C measures in non-orthogonal planes. In all, 3D3C OCT-based velocimetry has the potential to comprehensively characterize the flow performance of biological ciliated surfaces.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.