Evidence map›Paper›PMID 26417517›Full record

ArticleBiomedical optics express2015

Diverse effects of a 445 nm diode laser on isometric contraction of the rat aorta.

Sang Woong Park, Kyung Chul Shin, Hyun Ji Park, In Wha Lee, Hyung-Sik Kim, Soon-Cheol Chung, Ji-Sun Kim, Jae-Hoon Jun, Bokyung Kim, Young Min Bae

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sang Woong ParkDepartment of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, Chungbuk 380-701, South Korea.
Kyung Chul ShinDepartment of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, Chungbuk 380-701, South Korea.
Hyun Ji ParkDepartment of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, Chungbuk 380-701, South Korea.
In Wha LeeDepartment of Biomedical Engineering, BK21 + Research Institute of Biomedical Engineering, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk 380-701, South Korea.
Hyung-Sik KimDepartment of Biomedical Engineering, BK21 + Research Institute of Biomedical Engineering, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk 380-701, South Korea.
Soon-Cheol ChungDepartment of Biomedical Engineering, BK21 + Research Institute of Biomedical Engineering, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk 380-701, South Korea.
Ji-Sun KimDepartment of Biomedical Engineering, BK21 + Research Institute of Biomedical Engineering, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk 380-701, South Korea.
Jae-Hoon JunDepartment of Biomedical Engineering, BK21 + Research Institute of Biomedical Engineering, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk 380-701, South Korea.
Bokyung KimDepartment of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, Chungbuk 380-701, South Korea.
Young Min BaeDepartment of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, Chungbuk 380-701, South Korea.
Konkuk University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The usefulness of visible lasers in treating vascular diseases is controversial. It is probable that multiple effects of visible lasers on blood vessels and their unclear mechanisms have hampered the usefulness of this therapy. Therefore, elucidating the precise actions and mechanisms of the effects of lasers on blood vessels would provide insight into potential biomedical applications. Here, using organ chamber isometric contraction measurements, western blotting, patch-clamp, and en face immunohistochemistry, we showed that a 445 nm diode laser contracted rat aortic rings, both by activating endothelial nitric oxide synthase and by increasing oxidative stress. In addition to the effects on the endothelium, the laser also directly relaxed and contracted vascular smooth muscle by inhibiting L-type Ca(2+) channels and by activating protein tyrosine kinases, respectively. Thus, we conclude that exposure to 445 nm laser might contract and dilate blood vessels in the endothelium and smooth muscle via distinct mechanisms.

Indexed as

(140.3450) Laser-induced chemistry(140.7300) Visible lasers(170.0170) Medical optics and biotechnology(170.5380) Physiology

Identifiers

PMID26417517
PMCPMC4574673
OpenAlexW1852292342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.