ArticleBiomedical optics express2015
In vivo microscopy of hemozoin: towards a needle free diagnostic for malaria.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Noninvasive malaria detection beyond blood sampling.Sensors & diagnostics · 2026Review
- Hemozoin as a Diagnostic Biomarker: A Scoping Review of Next-Generation Malaria Detection Technologies.Biosensors · 2026Review
- Smartphone conjunctiva photography for malaria risk stratification in asymptomatic school age children.NPJ digital medicine · 2025Article
- Quantitative diffuse optical spectroscopy for noninvasive measurements of the malaria pigment hemozoin.Biomedical optics express · 2020Article
- Diamond Magnetic Microscopy of Malarial Hemozoin Nanocrystals.Physical review applied · 2019Article
- Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.Chemical reviews · 2019Review
- Towards a needle-free diagnosis of malaria: in vivo identification and classification of red and white blood cells containing haemozoin.Malaria journal · 2017Article
- Profile of Rebecca Richards-Kortum.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery.Biomedical optics express · 2016Article
- Introduction to the bio-optics: design and application.Biomedical optics express · 2015Article
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Authors and funding
3 authors.
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Abstract
Clinical diagnosis of malaria suffers from poor specificity leading to overtreatment with antimalarial medications. Alternatives, like blood smear microscopy or antigen-based tests, require a blood sample. We investigate in vivo microscopy as a needle-free malaria diagnostic. Two optical signatures, birefringence and absorbance, of the endogenous malaria by-product hemozoin were evaluated as in vivo optical biomarkers. Hemozoin birefringence was difficult to detect in highly scattering tissue; however, hemozoin absorbance was observed in increasingly complex biological environments and detectable over a clinically-relevant range of parasitemia in vivo in a P. yoelii-infected mouse model of malaria.
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