ArticleBiomedical optics express2015
Design of high-performance adaptive objective lens with large optical depth scanning range for ultrabroad near infrared microscopic imaging.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Miniature Deformable MEMS Mirrors for Ultrafast Optical Focusing.Micromachines · 2022Article
- Deformable mirror-based photoacoustic remote sensing (PARS) microscopy for depth scanning.Biomedical optics express · 2022Article
- Reduction of spherical and chromatic aberration in axial-scanning optical systems with tunable lenses.Biomedical optics express · 2021Article
- Dynamic Response of Elastomer-Based Liquid-Filled Variable Focus Lens.Sensors (Basel, Switzerland) · 2019Article
- A new low-cost, compact, auto-phoropter for refractive assessment in developing countries.Scientific reports · 2017Article
- Isotropic Elastic Stress Induced Large Temperature Range Liquid Crystal Blue Phase at Room Temperature.Journal of physical chemistry & biophysics · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We report on the theory and design of adaptive objective lens for ultra broadband near infrared light imaging with large dynamic optical depth scanning range by using an embedded tunable lens, which can find wide applications in deep tissue biomedical imaging systems, such as confocal microscope, optical coherence tomography (OCT), two-photon microscopy, etc., both in vivo and ex vivo. This design is based on, but not limited to, a home-made prototype of liquid-filled membrane lens with a clear aperture of 8mm and the thickness of 2.55mm ~3.18mm. It is beneficial to have an adaptive objective lens which allows an extended depth scanning range larger than the focal length zoom range, since this will keep the magnification of the whole system, numerical aperture (NA), field of view (FOV), and resolution more consistent. To achieve this goal, a systematic theory is presented, for the first time to our acknowledgment, by inserting the varifocal lens in between a front and a back solid lens group. The designed objective has a compact size (10mm-diameter and 15mm-length), ultrabroad working bandwidth (760nm - 920nm), a large depth scanning range (7.36mm in air) - 1.533 times of focal length zoom range (4.8mm in air), and a FOV around 1mm × 1mm. Diffraction-limited performance can be achieved within this ultrabroad bandwidth through all the scanning depth (the resolution is 2.22 μm - 2.81 μm, calculated at the wavelength of 800nm with the NA of 0.214 - 0.171). The chromatic focal shift value is within the depth of focus (field). The chromatic difference in distortion is nearly zero and the maximum distortion is less than 0.05%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.