ArticleBiomedical optics express2015
Periscope for noninvasive two-photon imaging of murine retina in vivo.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation.Progress in retinal and eye research · 2023Review
- Fluorescence Angiography with Dual Fluorescence for the Early Detection and Longitudinal Quantitation of Vascular Leakage in Retinopathy.Biomedicines · 2023Article
- Two-photon excitation fluorescence in ophthalmology: safety and improved imaging for functional diagnostics.Frontiers in medicine · 2023Review
- Intravital longitudinal cellular visualization of oral mucosa in a murine model based on rotatory side-view confocal endomicroscopy.Biomedical optics express · 2022Article
- Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo.Light, science & applications · 2020Article
- Non-invasive cellular-resolution retinal imaging with two-photon excited fluorescence.Biomedical optics express · 2019Article
- Retinal safety evaluation of two-photon laser scanning in rats.Biomedical optics express · 2019Article
- Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Two-photon phosphorescence lifetime microscopy of retinal capillary plexus oxygenation in mice.Journal of biomedical optics · 2018Article
- Two-photon imaging of the mammalian retina with ultrafast pulsing laser.JCI insight · 2018Article
- Volumetric fluorescence retinal imagingBiomedical optics express · 2018Article
- Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging.Scientific reports · 2016Article
- Image registration and averaging of low laser power two-photon fluorescence images of mouse retina.Biomedical optics express · 2016Article
- High-resolution contrast-enhanced optical coherence tomography in mice retinae.Journal of biomedical optics · 2016Article
- Longitudinal Intravital Imaging of the Retina Reveals Long-term Dynamics of Immune Infiltration and Its Effects on the Glial Network in Experimental Autoimmune Uveoretinitis, without Evident Signs of Neuronal Dysfunction in the Ganglion Cell Layer.Frontiers in immunology · 2016Article
- Effect of scanning beam size on the lateral resolution of mouse retinal imaging with SLO.Optics letters · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Two-photon microscopy allows visualization of subcellular structures in the living animal retina. In previously reported experiments it was necessary to apply a contact lens to each subject. Extending this technology to larger animals would require fitting a custom contact lens to each animal and cumbersome placement of the living animal head on microscope stage. Here we demonstrate a new device, periscope, for coupling light energy into mouse eye and capturing emitted fluorescence. Using this periscope we obtained images of the RPE and their subcellular organelles, retinosomes, with larger field of view than previously reported. This periscope provides an interface with a commercial microscope, does not require contact lens and its design could be modified to image retina in larger animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.