Evidence map›Paper›PMID 26417506›Full record

ArticleBiomedical optics express2015

Longitudinal far red gene-reporter imaging of cancer metastasis in preclinical models: a tool for accelerating drug discovery.

Banghe Zhu, Holly Robinson, Songlin Zhang, Grace Wu, Eva M Sevick-Muraca

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Banghe ZhuCenter for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, 77030, USA.
Holly RobinsonCenter for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, 77030, USA.
Songlin ZhangDepartment of Pathology, The University of Texas Medical School, Houston, Texas, 77030, USA.
Grace WuCenter for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, 77030, USA.
Eva M Sevick-MuracaCenter for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, 77030, USA.

Funding

Task Specific Project 4U54CA136404 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SEVICK, EVA M. · 2008 to 2012
$5.1M
Imaging lymph function in humans and in a murine model of lymphedemaR01CA128919 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SEVICK, EVA M. · 2008 to 2012
$1.5M
NCI NIH HHS R01 CA128919NCI NIH HHS U54 CA136404
6 · The paper itself

Abstract

In this short communication, we demonstrate for the first time, the use of far red fluorescent gene reporter, iRFP to longitudinally and non-invasively track the in vivo process of lymphatic metastases from an orthotopic site of mammary implantation through lymphatic vessels and to draining lymph nodes. Potentially useful to accelerate cancer drug discovery as an in vivo screening tool to monitor the pharmacological arrest of metastasis, we show that the custom as well as commercial small animal imaging devices have adequate performance to detect the gene reporter in stably expressing metastatic cancer cells.

Indexed as

(000.1430) Biology and medicine(040.1520) CCD, charge-coupled device(110.3080) Infrared imaging

Identifiers

PMID26417506
PMCPMC4574662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.