ArticleAnatomy & cell biology2015
Nfic regulates tooth root patterning and growth.
Article in Anatomy & cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Genetic analysis of three familial cases of pure terminal 19p13.3 duplication caused by maternal balanced translocation t(19;21) (p13.3;p12).Frontiers in genetics · 2026Article
- Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus.Nature communications · 2025Article
- Nuclear Factor I Family Members are Key Transcription Factors Regulating Gene Expression.Molecular & cellular proteomics : MCP · 2025Article
- A Wnt10a-Notch signaling axis controls Hertwig's epithelial root sheath cell behaviors during root furcation patterning.International journal of oral science · 2024Article
- The Development of Dentin Microstructure Is Controlled by the Type of Adjacent Epithelium.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Methylphenidate effects on mice odontogenesis and connections with human odontogenesis.Odontology · 2021Article
- USP34 regulates tooth root morphogenesis by stabilizing NFIC.International journal of oral science · 2021Article
- Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning.PLoS genetics · 2021Article
- Epithelial Bone Morphogenic Protein 2 and 4 Are Indispensable for Tooth Development.Frontiers in physiology · 2021Article
- Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh.Frontiers in cell and developmental biology · 2021Review
- Mesenchymal Progenitor Regulation of Tooth Eruption: A View from PTHrP.Journal of dental research · 2020Article
- [The role of bone morphogenetic protein signaling pathway in tooth root development].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018Review
- Signaling Pathways Critical for Tooth Root Formation.Journal of dental research · 2017Review
- The Impact of the Eda Pathway on Tooth Root Development.Journal of dental research · 2017Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular interactions between epithelium and mesenchyme are important for root formation. Nuclear factor I-C (Nfic) has been identified as a key regulator of root formation. However, the mechanisms of root formation and their interactions between Hertwig's epithelial root sheath (HERS) and mesenchyme remain unclear. In this study, we investigated the role of Nfic in root patterning and growth during molar root development. The molars of Nfic knockout mice exhibited an enlarged pulp chamber and apical displacement of the pulpal floor, characteristic features of taurodontism, due to delayed furcation formation. In developing molar roots of mutant mice at P14, BrdU positive cells decreased in the apical mesenchyme of the elongation region whereas those cells increased in the dental papilla of the furcation region. Whereas cytokeratin 14 and laminin were localized in HERS cells of mutant molars, Smoothened (Smo) and Gli1 were downregulated in preodontoblasts. In contrast, cytokeratin 14 and Smo were localized in the cells of the furcation region of mutant molars. These results indicate that Nfic regulates cell proliferation in the dental mesenchyme and affects the fate of HERS cells in a site-specific manner. From the results, it is suggested that Nfic is required for root patterning and growth during root morphogenesis.
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