ArticleEvidence-based complementary and alternative medicine : eCAM2015
Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review.BMC veterinary research · 2019Pooled it
- Effect of St. John's wort oil and olive oil on the postoperative complications after third molar surgery: randomized, double-blind clinical trial.Clinical oral investigations · 2021Trial
- Evaluation of Wound-Healing Potential of Plant Extracts via Picture Fuzzy Multi-Attribute Decision-Making.ACS omega · 2026Article
- Effect ofFrontiers in dentistry · 2026Article
- Strategies for Incorporating Natural Therapeutic Agents into Hydrogel Dressings: Innovations in Wound Healing.Polymers · 2025Review
- Healing Effects of Luteolin Versus Silver Sulphadiazine on Second-Degree Burn Wounds in Animal Model.Galen medical journal · 2024Article
- Evaluation of the Effectiveness of Medical-Grade Honey and Hypericum Perforatum Ointment on Second-Intention Healing of Full-Thickness Skin Wounds in Cats.Animals : an open access journal from MDPI · 2023Article
- Emulsion Electrospinning of PLLA/PVA/Chitosan withGels (Basel, Switzerland) · 2023Article
- Herbal Products and Their Active Constituents for Diabetic Wound Healing-Preclinical and Clinical Studies: A Systematic Review.Pharmaceutics · 2023Review
- Effect of topicalJournal of advanced veterinary and animal research · 2021Article
- Protective Role of St. John's Wort and Its Components Hyperforin and Hypericin against Diabetes through Inhibition of Inflammatory Signaling: Evidence from In Vitro and In Vivo Studies.International journal of molecular sciences · 2020Review
- Evaluation of the Effect ofDrug design, development and therapy · 2020Article
- The role of Iranian medicinal plants in experimental surgical skin wound healing: An integrative review.Iranian journal of basic medical sciences · 2019Review
- Effect of Honey/PVA Hydrogel Loaded by Erythromycin on Full-Thickness Skin Wound Healing in Rats; Stereological Study.Galen medical journal · 2019Article
- The Healing Effect ofWorld journal of plastic surgery · 2019Article
- The effect ofEuropean oral research · 2018Article
- A Perspective on Hypericum perforatum Genetic Transformation.Frontiers in plant science · 2016Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delayed wound healing process is one of the most important concerns in diabetes. Healing of wounds has four phases, namely, hemostasis, inflammation, proliferation, and remodeling. For a successful repair, all four factors must occur properly. Hence, we aimed to evaluate the healing effects of Hypericum perforatum (HP) on full-thickness diabetic skin wounds by using stereological methods. Forty-eight female diabetic rats were randomly divided into four groups (n = 12): gel base treated group, HP 5% gel treated group, HP 10% gel treated group, and the control group which received no treatment. A circular 1 cm(2) full-thickness wound was created on the animal's neck and wound area was measured every three days. After sacrificing the animals, skin samples were fixed and prepared for stereological evaluations. Based on the results, HP treated group showed faster wound closure rate in comparison with control and vehicle groups (P < 0.05). In addition, numerical density of fibroblasts, volume density of collagen bundles, and mean diameter and volume densities of the vessels in HP group were significantly higher than control and vehicle groups. The results of this study showed that HP has the ability to improve tissue regeneration by enhancing fibroblast proliferation, collagen bundle synthesis, and revascularization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.