Evidence map›Paper›PMID 26417314›Full record

ReviewEXCLI journal2014

Epigenetics in diagnosis, prognostic assessment and treatment of cancer: an update.

Eleftheria Hatzimichael, Konstantinos Lagos, Van Ren Sim, Evangelos Briasoulis, Tim Crook

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in EXCLI journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eleftheria HatzimichaelDepartment of Haematology, University Hospital of Ioannina, Ioannina, Greece.
Konstantinos LagosDepartment of Haematology, University Hospital of Ioannina, Ioannina, Greece.
Van Ren SimDundee Cancer Center, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Evangelos BriasoulisDepartment of Haematology, University Hospital of Ioannina, Ioannina, Greece.
Tim CrookDundee Cancer Center, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells contain multiple genetic and epigenetic changes. The relative specificity of many epigenetic changes for neoplastic cells has allowed the identification of diagnostic, prognostic and predictive biomarkers for a number of solid tumors and hematological malignancies. Moreover, epigenetically-acting drugs are already in routine use for cancer and numerous additional agents are in clinical trials. Here, we review recent progress in the development and application of epigenetic strategies for the diagnosis, risk stratification and treatment of cancer.

Indexed as

acetylationcancerdiagnosisepigeneticshematological malignancieshypomethylating agentsmethylationtreatment

Identifiers

PMID26417314
PMCPMC4464089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.