Evidence map›Paper›PMID 26417202›Full record

ReviewSubstance abuse : research and treatment2015

Impact of Chronic Pain on Treatment Prognosis for Patients with Opioid Use Disorder: A Systematic Review and Meta-analysis.

Brittany B Dennis, Monica Bawor, Leen Naji, Carol K Chan, Jaymie Varenbut, James Paul, Michael Varenbut, Jeff Daiter, Carolyn Plater, Guillaume Pare and 5 more

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Substance abuse : research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07148206 (Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07148206 phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial

TypeinterventionalSponsorMontefiore Medical CenterRan2026 to 2028Enrolled40ConditionsOpioid Use DisorderArmsDronabinol Capsules, Epidiolex 100 mg/mL Oral Solution, Placebo Dronabinol, Placebo Epidiolex
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Chronic pain and opioid misuse: a review of reviews.Substance abuse treatment, prevention, and policy · 2017
    Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Developing a novel treatment for patients with chronic pain and Opioid User Disorder.Substance abuse treatment, prevention, and policy · 2022
    Trial
  10. Article
  11. Article
  12. Article
  13. Article
  14. A conceptual framework for the public health monitoring of substance-related harms.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. Noninvasive Vagal Nerve Stimulation for Opioid Use Disorder.Annals of depression and anxiety · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Brittany B DennisDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. ; Population Genomics Program, Chanchlani Research Centre, McMaster University, Hamilton, ON, Canada.
Monica BaworPopulation Genomics Program, Chanchlani Research Centre, McMaster University, Hamilton, ON, Canada. ; McMaster Integrative Neuroscience Discovery and Study (MiNDS) Program, McMaster University, Hamilton, ON, Canada.
Leen NajiMichael G. Degroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Carol K ChanSchool of Medicine and Medical Science, University College Dublin, Dublin, Ireland.
Jaymie VarenbutDepartment of Biological Sciences, Western University, London, ON, Canada.
James PaulDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. ; Department of Anesthesia, McMaster University, Hamilton, ON, Canada.
Michael VarenbutCanadian Addiction Treatment Centres, Richmond Hill, ON, Canada.
Jeff DaiterCanadian Addiction Treatment Centres, Richmond Hill, ON, Canada.
Carolyn PlaterCanadian Addiction Treatment Centres, Richmond Hill, ON, Canada.
Guillaume PareDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
David C MarshCanadian Addiction Treatment Centres, Richmond Hill, ON, Canada. ; Northern Ontario School of Medicine, Sudbury, ON, Canada.
Andrew WorsterCanadian Addiction Treatment Centres, Richmond Hill, ON, Canada. ; Department of Medicine, Hamilton General Hospital, Hamilton, ON, Canada.
Dipika DesaiPopulation Genomics Program, Chanchlani Research Centre, McMaster University, Hamilton, ON, Canada. ; Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada.
Lehana ThabaneDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. ; Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada. ; Departments of Pediatrics and Anesthesia, McMaster University, Hamilton, ON Canada. ; Centre for Evaluation of Medicine, St Joseph's Healthcare, Hamilton, ON, Canada. ; Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare, Hamilton, ON, Canada.
Zainab SamaanDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. ; Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada. ; Peter Boris Centre for Addictions Research, Hamilton, ON, Canada.
McMaster University · CAPopulation Health Research Institute · CAHamilton General Hospital · CANOSM University · CAUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile a number of pharmacological interventions exist for the treatment of opioid use disorder, evidence evaluating the effect of pain on substance use behavior, attrition rate, and physical or mental health among these therapies has not been well established. We aim to evaluate these effects using evidence gathered from a systematic review of studies evaluating chronic non-cancer pain (CNCP) in patients with opioid use disorder.

methodsWe searched the Medline, EMBASE, PubMed, PsycINFO, Web of Science, Cochrane Database of Systematic Reviews, ProQuest Dissertations and theses Database, Cochrane Central Register of Controlled Trials, World Health Organization International Clinical Trials Registry Platform Search Portal, and National Institutes for Health Clinical Trials Registry databases to identify articles evaluating the impact of pain on addiction treatment outcomes for patients maintained on opioid agonist therapy.

resultsUpon screening 3,540 articles, 14 studies with a combined sample of 3,128 patients fulfilled the review inclusion criteria. Results from the meta-analysis suggest that pain has no effect on illicit opioid consumption [pooled odds ratio (pOR): 0.70, 95%CI 0.41-1.17; I (2) = 0.0] but a protective effect for reducing illicit non-opioid substance use (pOR: 0.57, 95%CI 0.41-0.79; I (2) = 0.0). Studies evaluating illicit opioid consumption using other measures demonstrate pain to increase the risk for opioid abuse. Pain is significantly associated with the presence of psychiatric disorders (pOR: 2.18; 95%CI 1.6, 2.9; I (2) = 0.0%).

conclusionCNCP may increase risk for continued opioid abuse and poor psychiatric functioning. Qualitative synthesis of the findings suggests that major methodological differences in the design and measurement of pain and treatment response outcomes are likely impacting the effect estimates.

Indexed as

chronic painguidelinesmeta-analysisopioid substitution therapyopioid use disordersystematic review

Identifiers

PMID26417202
PMCPMC4573077
OpenAlexW2123686376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.