ReviewBiomarker insights2015
Biomarkers for Sepsis: What Is and What Might Be?
Review in Biomarker insights, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed.
- Metabolic profiles in community-acquired pneumonia: developing assessment tools for disease severity.Critical care (London, England) · 2018Trial
- Activation of the Cerebrospinal Fluid-Contacting Nucleus Mitigates Systemic Inflammation Induced by Sepsis.Shock (Augusta, Ga.) · 2026Article
- Soluble triggering receptor expressed on myeloid cells-1 as a predictive biomarker in sepsis: insights into cut-offs, mortality risk, and treatment guidance-secondary analysis of the Next GeneSiS-Trial.Critical care (London, England) · 2026Observational
- Impact of cardiovascular and metabolic comorbidities on severity and outcomes of hospital-acquired sepsis in intensive care patients: a case-control study.BMC infectious diseases · 2026Article
- A Reproducible Ceramide Phenotype of Sepsis Across Aetiologies - A Monocenter Cohort Study.Journal of inflammation research · 2026Article
- Differential Effects of Endothelial Cell- as opposed to Neutrophil-Lineage Restricted PD-L1 Gene Expression on Experimental Murine Shock/ Sepsis-Induced Lung Injury.Research square · 2025Article
- Mechanisms of immune suppression in sepsis/shock: one investigator's/lab group's experience (SLB 2024 legacy award presentation).Journal of leukocyte biology · 2025Article
- SEPSIGN: early identification of sepsis signs in emergency department.Internal and emergency medicine · 2025Observational
- Elevated total bile acid levels as an independent predictor of mortality in pediatric sepsis.Pediatric research · 2025Article
- Value of animal sepsis research in navigating the translational labyrinth.Frontiers in immunology · 2025Article
- Case Report: A rare case of community-acquiredFrontiers in immunology · 2025Article
- Comparison of the accuracy of procalcitonin, neutrophil CD64, and C-reactive protein for the diagnosis and prognosis of septic patients after antibiotic therapy.Practical laboratory medicine · 2025Article
- Review
- Challenges and Advances in Biomarker Detection for Rapid and Accurate Sepsis Diagnosis: An Electrochemical Approach.Biosensors · 2024Review
- A 29-mRNA host-response classifier identifies bacterial infections following liver transplantation - a pilot study.Langenbeck's archives of surgery · 2024Observational
- The Potential Role of Presepsin in Predicting Severe Infection in Patients with Diabetic Foot Ulcers.Journal of clinical medicine · 2024Article
- Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores.Journal of inflammation (London, England) · 2024Article
- Platelet P2YBritish journal of pharmacology · 2024Review
- Biomarkers for Serious Bacterial Infections in Febrile Children.Biomolecules · 2024Review
- Serum Insulin-like Growth Factor-Binding Protein-2 as a Prognostic Factor for COVID-19 Severity.Biomedicines · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Every year numerous individuals develop the morbid condition of sepsis. Therefore, novel biomarkers that might better inform clinicians treating such patients are sorely needed. Difficulty in identifying such markers is in part due to the complex heterogeneity of sepsis, resulting from the broad and vague definition of this state/condition based on numerous possible clinical signs and symptoms as well as an incomplete understanding of the underlying pathobiology of this complex condition. This review considers some of the attempts that have been made so far, looking at both the pro- and anti-inflammatory response to sepsis, as well as genomic analysis, as sources of potential biomarkers. Irrespective, for functional biomarker(s) of sepsis to successfully translate from the laboratory to a clinical setting, the biomarker must be target specific and sensitive as well as easy to implement/interpret, and be cost effective, such that they can be utilized routinely in patient diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.