ArticleProceedings of the National Academy of Sciences of the United States of America2015
A parasitic nematode releases cytokinin that controls cell division and orchestrates feeding site formation in host plants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 154 citations in OpenAlex.
- Quantitative live-cell imaging of auxin and cytokinin signalling in developing feeding sites ofPlant signaling & behavior · 2026Article
- Root-knot-nematode-derived mimics of RGF peptides hijack host signalling to orchestrate feeding site formation.Nature plants · 2026Article
- Integrated omics reveal phenylpropanoid biosynthesis as a key defense pathway against Meloidogyne incognita in Cucumis metuliferus.BMC plant biology · 2026Article
- A multi-omics approach reveals that the plant-parasitic nematodeParasitology · 2026Article
- Biocontrol of Root-Knot Nematodes via siRNA-Loaded Extracellular Vesicles From a Nematophagous Fungus Arthrobotrys oligospora.Microbial biotechnology · 2025Article
- From germplasm to genomics: integrated breeding and omics approaches for enhancing rice root knot nematode resistance in Direct-Seeded Rice systems.Molecular biology reports · 2025Review
- Identification of Bioactive Peptides fromMicroorganisms · 2025Article
- Cellular plasticity and transcriptional reprogramming in plant-nematode interactions: insights into feeding site formation and plant defense.Crop health · 2025Review
- Allies or Enemies? The Power of Plant Hormones in Animals: Insights into Their Regulatory Roles.Molecules (Basel, Switzerland) · 2025Review
- Insights into the roles of chromatin-remodeling complex HOS15-PWR-HDA9 in plant development and stress responses.Plant cell reports · 2025Review
- A long-distance inhibitory system regulates haustoria numbers in parasitic plants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Discovery of two tightly linked soybean genes at the qSCN10 (O) locus conferring broad-spectrum resistance to soybean cyst nematode.Communications biology · 2025Article
- Laser dissection-assisted phloem transcriptomics highlights the metabolic and physiological changes accompanying clubroot disease progression in oilseed rape.The Plant journal : for cell and molecular biology · 2025Article
- Mesenchymal Stem Cells Carrying Viral Fusogenic Protein p14 to Treat Solid Tumors by Inducing Cell-Cell Fusion and Immune Activation.Research (Washington, D.C.) · 2025Article
- Cytokinin Plays a Multifaceted Role in Ralstonia solanacearum-Triggered Plant Disease Development.Molecular plant pathology · 2024Article
- A major role of class III HD-ZIPs in promoting sugar beet cyst nematode parasitism in Arabidopsis.PLoS pathogens · 2024Article
- Cytokinin: From autoclaved DNA to two-component signaling.The Plant cell · 2024Review
- Soybean MKK2 establishes intricate signalling pathways to regulate soybean response to cyst nematode infection.Molecular plant pathology · 2024Article
- Syncytium Induced by Plant-Parasitic Nematodes.Results and problems in cell differentiation · 2024Review
- Functional studies of plant transcription factors and their relevance in the plant root-knot nematode interaction.Frontiers in plant science · 2024Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sedentary plant-parasitic cyst nematodes are biotrophs that cause significant losses in agriculture. Parasitism is based on modifications of host root cells that lead to the formation of a hypermetabolic feeding site (a syncytium) from which nematodes withdraw nutrients. The host cell cycle is activated in an initial cell selected by the nematode for feeding, followed by activation of neighboring cells and subsequent expansion of feeding site through fusion of hundreds of cells. It is generally assumed that nematodes manipulate production and signaling of the plant hormone cytokinin to activate cell division. In fact, nematodes have been shown to produce cytokinin in vitro; however, whether the hormone is secreted into host plants and plays a role in parasitism remained unknown. Here, we analyzed the spatiotemporal activation of cytokinin signaling during interaction between the cyst nematode, Heterodera schachtii, and Arabidopsis using cytokinin-responsive promoter:reporter lines. Our results showed that cytokinin signaling is activated not only in the syncytium but also in neighboring cells to be incorporated into syncytium. An analysis of nematode infection on mutants that are deficient in cytokinin or cytokinin signaling revealed a significant decrease in susceptibility of these plants to nematodes. Further, we identified a cytokinin-synthesizing isopentenyltransferase gene in H. schachtii and show that silencing of this gene in nematodes leads to a significant decrease in virulence due to a reduced expansion of feeding sites. Our findings demonstrate the ability of a plant-parasitic nematode to synthesize a functional plant hormone to manipulate the host system and establish a long-term parasitic interaction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.