ArticleProceedings of the National Academy of Sciences of the United States of America2015
Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Characterizing Spatial Associations Between GluCEST MRI and Neurotransmitter Receptor Density in the Human Cortex.Human brain mapping · 2025Article
- Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development.Nature communications · 2024Article
- Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS.Nature reviews. Neuroscience · 2021Review
- Article
- Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.Frontiers in neural circuits · 2021Review
- Impairment of synaptic plasticity and novel object recognition in the hypergravity-exposed rats.Scientific reports · 2020Article
- Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity.Nature communications · 2020Article
- Distinct Laminar Requirements for NMDA Receptors in Experience-Dependent Visual Cortical Plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Article
- G protein-coupled receptors in acquired epilepsy: Druggability and translatability.Progress in neurobiology · 2019Review
- Early Loss of Vision Results in Extensive Reorganization of Plasticity-Related Receptors and Alterations in Hippocampal Function That Extend Through Adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Arc restores juvenile plasticity in adult mouse visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Infantile Amnesia: A Critical Period of Learning to Learn and Remember.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- LTD-like molecular pathways in developmental synaptic pruning.Nature neuroscience · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A feature of early postnatal neocortical development is a transient peak in signaling via metabotropic glutamate receptor 5 (mGluR5). In visual cortex, this change coincides with increased sensitivity of excitatory synapses to monocular deprivation (MD). However, loss of visual responsiveness after MD occurs via mechanisms revealed by the study of long-term depression (LTD) of synaptic transmission, which in layer 4 is induced by acute activation of NMDA receptors (NMDARs) rather than mGluR5. Here we report that chronic postnatal down-regulation of mGluR5 signaling produces coordinated impairments in both NMDAR-dependent LTD in vitro and ocular dominance plasticity in vivo. The data suggest that ongoing mGluR5 signaling during a critical period of postnatal development establishes the biochemical conditions that are permissive for activity-dependent sculpting of excitatory synapses via the mechanism of NMDAR-dependent LTD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.