Evidence map›Paper›PMID 26417041›Full record

ArticleDevelopment (Cambridge, England)2015

Excitability governs neural development in a hippocampal region-specific manner.

Erin M Johnson-Venkatesh, Mudassar N Khan, Geoffrey G Murphy, Michael A Sutton, Hisashi Umemori

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  10. Review
  11. Construction and disruption of spatial memory networks during development.Learning & memory (Cold Spring Harbor, N.Y.) · 2019
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Erin M Johnson-VenkateshDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA Molecular & Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Mudassar N KhanMolecular & Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Geoffrey G MurphyMolecular & Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Michael A SuttonMolecular & Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA masutton@umich.edu hisashi.umemori@childrens.harvard.edu.
Hisashi UmemoriDepartment of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA Molecular & Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA masutton@umich.edu hisashi.umemori@childrens.harvard.edu.
University of Michigan–Ann Arbor · US

Funding

Investigating CD47-SIRPa as novel protective signals during CNS synaptic pruningR01NS092578 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI STEVENS, BETH ANN, UMEMORI, HISASHI · 2015 to 2019
$2.9M
Activity-Dependent Synapse Refinement in the Memory Circuit in vivoR01MH091429 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI UMEMORI, HISASHI · 2010 to 2014
$2.0M
Local Homeostatic Control of Synapse FunctionR01MH085798 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUTTON, MICHAEL MARK ALEXANDER · 2010 to 2014
$1.9M
NIMH NIH HHS MH085798NIMH NIH HHS MH091429NIMH NIH HHS R01 MH085798NIMH NIH HHS R01 MH091429NINDS NIH HHS R01 NS092578
6 · The paper itself

Abstract

Neuronal activity, including intrinsic neuronal excitability and synaptic transmission, is an essential regulator of brain development. However, how the intrinsic neuronal excitability of distinct neurons affects their integration into developing circuits remains poorly understood. To investigate this problem, we created several transgenic mouse lines in which intrinsic excitability is suppressed, and the neurons are effectively silenced, in different excitatory neuronal populations of the hippocampus. Here we show that CA1, CA3 and dentate gyrus neurons each have unique responses to suppressed intrinsic excitability during circuit development. Silenced CA1 pyramidal neurons show altered spine development and synaptic transmission after postnatal day 15. By contrast, silenced CA3 pyramidal neurons seem to develop normally. Silenced dentate granule cells develop with input-specific decreases in spine density starting at postnatal day 11; however, a compensatory enhancement of neurotransmitter release onto these neurons maintains normal levels of synaptic activity. The synaptic changes in CA1 and dentate granule neurons are not observed when synaptic transmission, rather than intrinsic excitability, is blocked in these neurons. Thus, our results demonstrate a crucial role for intrinsic neuronal excitability in establishing hippocampal connectivity and reveal that neuronal development in each hippocampal region is distinctly regulated by excitability.

Indexed as

Analysis of VarianceAnimalsCA1 Region, HippocampalCA3 Region, HippocampalCell CountDendritesDentate GyrusHippocampusImmunohistochemistryMiceMice, TransgenicMicroscopy, ConfocalNeurogenesisNeuronsPyramidal CellsSynaptic TransmissionDendritic spinesHippocampusNeural activitySynaptogenesisTransgenic mice

Identifiers

PMID26417041
PMCPMC4712876
OpenAlexW2178721199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.