Evidence map›Paper›PMID 26417035›Full record

Trial reportCirculation. Cardiovascular genetics2015

Susceptibility Loci for Clinical Coronary Artery Disease and Subclinical Coronary Atherosclerosis Throughout the Life-Course.

Elias Salfati, Shuktika Nandkeolyar, Stephen P Fortmann, Stephen Sidney, Mark A Hlatky, Thomas Quertermous, Alan S Go, Carlos Iribarren, David M Herrington, Benjamin A Goldstein and 1 more

Open access · bronzeAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Cardiovascular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Genetics of Subclinical Coronary Atherosclerosis.Current genetic medicine reports · 2018
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Elias SalfatiFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.).
Shuktika NandkeolyarFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.).
Stephen P FortmannFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.).
Stephen SidneyFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.).
Mark A HlatkyFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.).
Thomas QuertermousFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.).
Alan S GoFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.).
Carlos IribarrenFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.).
David M HerringtonFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.).
Benjamin A GoldsteinFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.).
Themistocles L AssimesFrom the Department of Medicine, Stanford University School of Medicine, CA (E.S., S.P.F., M.A.H., T.Q., B.A.G., T.L.A.); Ecole Doctorale B2T, IUH, Université Paris 7, Paris, France (E.S.); Medical College of Wisconsin, Milwaukee (S.N.); Kaiser Permanente Center for Health Research, Portland, OR (S.P.F.); Kaiser Permanente Division of Research, Oakland, CA (S.S., A.S.G., C.I.); Heart and Vascular Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.); and Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.A.G.). tassimes@stanford.edu.
Medical College of Wisconsin · USKaiser Permanente Center for Health Research · USWake Forest University · USKaiser Permanente · US

Funding

SNPs and Extent of Atherosclerosis (SEA) StudyU01HL080443 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HERRINGTON, DAVID MCLEOD · 2006 to 2009
$8.7M
Whole Genome Association for Early Coronary Artery Disease and Related PhenotypesR01HL087647 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2006 to 2008
$4.6M
Molecular Mechanisms of Insulin Resistance Associated LociR01DK107437 · NIDDK · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2016 to 2019
$2.2M
Identification of causal coronary heart disease variation in smooth muscle cellsR33HL120757 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2016 to 2018
$1.6M
Understanding and predicting cardiac events in HD using real-time EHRsK25DK097279 · NIDDK · STANFORD UNIVERSITY · PI GOLDSTEIN, BENJAMIN ALAN · 2013 to 2017
$797k
Determinants of Insulin Mediated Glucose uptake in South AsiansK23DK088942 · NIDDK · STANFORD UNIVERSITY · PI ASSIMES, THEMISTOCLES LEONARD · 2011 to 2014
$724k
NHLBI NIH HHS HL087647NHLBI NIH HHS R01 HL087647NHLBI NIH HHS R33 HL120757NHLBI NIH HHS U01 HL080443NIDDK NIH HHS K23 DK088942NIDDK NIH HHS K23DK088942NIDDK NIH HHS K25 DK097279NIDDK NIH HHS R01 DK107437
6 · The paper itself

Abstract

backgroundRecent genome-wide association studies have identified 49 single nucleotide polymorphisms associated with clinical coronary artery disease. The mechanism by which these loci influence risk remains largely unclear. METHODS AND

resultsWe examined the association between a genetic risk score composed of high-risk alleles at the 49 single nucleotide polymorphisms and the degree of subclinical coronary atherosclerosis in 7798 participants from 6 studies stratified into 4 age groups at the time of assessment (15-34, 35-54, 55-74, and >75 years). Atherosclerosis was quantified by staining and direct visual inspection of the right coronary artery in the youngest group and by scanning for coronary artery calcification in the remaining groups. We defined cases as subjects within the top quartile of degree of atherosclerosis in 3 groups and as subjects with a coronary artery calcium score >0 in the fourth (35-54 years) where less than one quarter had any coronary artery calcium. In our meta-analysis of all strata, we found 1-SD increase in the genetic risk score increased the risk of advanced subclinical coronary atherosclerosis by 36% (P=8.3×10(-25)). This increase in risk was significant in all 4 age groups including the youngest group where atherosclerosis consisted primarily of raised lesions without macroscopic evidence of plaque rupture or thrombosis. Results were similar when we restricted the genetic risk score to 32 single nucleotide polymorphisms not associated with traditional risk factors or when we adjusted for traditional risk factors.

conclusionsA genetic risk score for clinical coronary artery disease is associated with advanced subclinical coronary atherosclerosis throughout the life-course. This association is apparent even at the earliest, uncomplicated stages of atherosclerosis.

Indexed as

AgingGenetic LociGenetic Predisposition to DiseasePolymorphism, Single NucleotideAdolescentAdultAgedCase-Control StudiesCoronary Artery DiseaseFemaleHumansMaleMiddle Agedatherosclerosiscoronary artery diseasegeneticshumansmolecular epidemiology

Identifiers

PMID26417035
PMCPMC4824193
OpenAlexW2582308230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.