ArticlePlant physiology2015
Functional Analysis of the Arabidopsis TETRASPANIN Gene Family in Plant Growth and Development.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Functional insights into dispensable genes using genome-wide loss-of-function burden tests in Arabidopsis.The Plant cell · 2026Article
- Comparative proteomics reveals protein signatures shared between and unique to bona fide plant EVs and other plant-derived vesicles.Plant physiology · 2026Article
- Tetraspanin OsTET8 acts as a negative regulator of root development in rice.Rice (New York, N.Y.) · 2025Article
- Drought recovery in plants triggers a cell-state-specific immune activation.Nature communications · 2025Article
- Tetraspanin 5 orchestrates resilience to salt stress through the regulation of ion and reactive oxygen species homeostasis in rice.Plant biotechnology journal · 2025Article
- Identification of the tetraspanin gene family in sugarcane and its response to sugarcane mosaic virus infection.Frontiers in plant science · 2025Article
- Single-cell transcriptomic analysis of flowering regulation and vernalization in Chinese cabbage shoot apex.Horticulture research · 2024Article
- Arabidopsis apoplast TET8 positively correlates to leaf senescence, andPlant direct · 2024Article
- Fine mapping and identification of two NtTOM2A homeologs responsible for tobacco mosaic virus replication in tobacco (Nicotiana tabacum L.).BMC plant biology · 2024Article
- Isolation and Characterization of Extracellular Vesicles fromPlants (Basel, Switzerland) · 2023Article
- TETRASPANIN 8-1 fromFrontiers in plant science · 2023Article
- Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage.Genome biology · 2022Article
- Integration of transcriptomic and proteomic analyses reveals several levels of metabolic regulation in the excess starch and early senescent leaf mutant lses1 in rice.BMC plant biology · 2022Article
- Overexpression of GhKTI12 Enhances Seed Yield and Biomass Production in Nicotiana Tabacum.Genes · 2022Article
- Arabidopsis Tetraspanins Facilitate Virus InfectionFrontiers in plant science · 2022Article
- Plasmodesmata Structural Components and Their Role in Signaling and Plant Development.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Message in a Bubble: Shuttling Small RNAs and Proteins Between Cells and Interacting Organisms Using Extracellular Vesicles.Annual review of plant biology · 2021Review
- Combined Transcriptome Analysis Reveals the Ovule Abortion Regulatory Mechanisms in the Female Sterile Line ofInternational journal of molecular sciences · 2021Article
- The Roles of Plant Hormones and Their Interactions with Regulatory Genes in Determining Meristem Activity.International journal of molecular sciences · 2019Review
- A tetraspanin gene regulating auxin response and affecting orchid perianth size and various plant developmental processes.Plant direct · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TETRASPANIN (TET) genes encode conserved integral membrane proteins that are known in animals to function in cellular communication during gamete fusion, immunity reaction, and pathogen recognition. In plants, functional information is limited to one of the 17 members of the Arabidopsis (Arabidopsis thaliana) TET gene family and to expression data in reproductive stages. Here, the promoter activity of all 17 Arabidopsis TET genes was investigated by pAtTET::NUCLEAR LOCALIZATION SIGNAL-GREEN FLUORESCENT PROTEIN/β-GLUCURONIDASE reporter lines throughout the life cycle, which predicted functional divergence in the paralogous genes per clade. However, partial overlap was observed for many TET genes across the clades, correlating with few phenotypes in single mutants and, therefore, requiring double mutant combinations for functional investigation. Mutational analysis showed a role for TET13 in primary root growth and lateral root development and redundant roles for TET5 and TET6 in leaf and root growth through negative regulation of cell proliferation. Strikingly, a number of TET genes were expressed in embryonic and seedling progenitor cells and remained expressed until the differentiation state in the mature plant, suggesting a dynamic function over developmental stages. The cis-regulatory elements together with transcription factor-binding data provided molecular insight into the sites, conditions, and perturbations that affect TET gene expression and positioned the TET genes in different molecular pathways; the data represent a hypothesis-generating resource for further functional analyses.
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