ArticleThe Journal of cell biology2015
Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Intercellular adhesion boots collective cell migration through elevated membrane tension.Nature communications · 2025Article
- Plakophilin-3 Binds the Membrane and Filamentous Actin without Bundling F-Actin.International journal of molecular sciences · 2023Article
- Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin.Journal of cell science · 2021Article
- First report of a Mexican family with mutation in the CDH1 gene.Molecular genetics & genomic medicine · 2020Article
- Afadin regulates actomyosin organization through αE-catenin at adherens junctions.The Journal of cell biology · 2020Article
- An optochemical tool for light-induced dissociation of adherens junctions to control mechanical coupling between cells.Nature communications · 2020Article
- Vinculin anchors contractile actin to the cardiomyocyte adherens junction.Molecular biology of the cell · 2019Article
- Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin.Nature cell biology · 2018Article
- Nonmuscle myosin IIA is involved in recruitment of apical junction components through activation of α-catenin.Biology open · 2018Article
- The role of adherens junction proteins in the regulation of insulin secretion.Bioscience reports · 2018Review
- Germline mutations in hereditary diffuse gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2018Article
- Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells.Cold Spring Harbor perspectives in biology · 2017Review
- Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin.Journal of cell science · 2017Article
- Phosphorylation potential ofDevelopment (Cambridge, England) · 2017Article
- The VE-cadherin cytoplasmic domain undergoes proteolytic processing during endocytosis.Molecular biology of the cell · 2017Article
- αT-Catenin Is a Constitutive Actin-binding α-Catenin That Directly Couples the Cadherin·Catenin Complex to Actin Filaments.The Journal of biological chemistry · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
As part of the E-cadherin-β-catenin-αE-catenin complex (CCC), mammalian αE-catenin binds F-actin weakly in the absence of force, whereas cytosolic αE-catenin forms a homodimer that interacts more strongly with F-actin. It has been concluded that cytosolic αE-catenin homodimer is not important for intercellular adhesion because E-cadherin/αE-catenin chimeras thought to mimic the CCC are sufficient to induce cell-cell adhesion. We show that, unlike αE-catenin in the CCC, these chimeras homodimerize, bind F-actin strongly, and inhibit the Arp2/3 complex, all of which are properties of the αE-catenin homodimer. To more accurately mimic the junctional CCC, we designed a constitutively monomeric chimera, and show that E-cadherin-dependent cell adhesion is weaker in cells expressing this chimera compared with cells in which αE-catenin homodimers are present. Our results demonstrate that E-cadherin/αE-catenin chimeras used previously do not mimic αE-catenin in the native CCC, and imply that both CCC-bound monomer and cytosolic homodimer αE-catenin are required for strong cell-cell adhesion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.