Trial reportPediatrics2015
Bladder Function After Fetal Surgery for Myelomeningocele.
Trial report in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00060606 (Myelomeningocele Repair Randomized Trial), which is not on this map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Myelomeningocele Repair Randomized Trial
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Benefits and complications of fetal and postnatal surgery for open spina bifida: systematic review and proportional meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Pooled it
- Preclinical stem cell therapy in fetuses with myelomeningocele: A systematic review and meta-analysis.Prenatal diagnosis · 2021Pooled it
- Cranial findings detected by second-trimester ultrasound in fetuses with myelomeningocele: a systematic review.BJOG : an international journal of obstetrics and gynaecology · 2021Pooled it
- The Management of Myelomeningocele Study: Short-Term Neonatal Outcomes.Fetal diagnosis and therapy · 2020Trial
- The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes.American journal of obstetrics and gynecology · 2018Trial
- Quality of life in children with myelomeningocele undergoing intrauterine repair and postnatal surgery.The journal of spinal cord medicine · 2026Article
- Prenatal Diagnosis to Postnatal Outcomes of Saccular Forms of Closed Spina Dysraphism: A Single Center Retrospective Study.Prenatal diagnosis · 2026Article
- Neural Tube Defects in Resource-Limited Settings: A Lebanese Case Series Highlighting Prevention Gaps and Challenges in Prenatal Diagnosis.Case reports in obstetrics and gynecology · 2026Article
- Urological, Digestive and Motor Function in Children After Prenatal or Postnatal Repair of Myelomeningocele.Pediatric reports · 2025Article
- Implementation ofAJOG global reports · 2025Article
- Stratification of neurogenic bladder risk in spina bifida using the urinary peptidome.American journal of physiology. Renal physiology · 2024Article
- Fetal Surgery for Myelomeningocele: Neurosurgical Perspectives.Advances and technical standards in neurosurgery · 2023Article
- Early investigations into improving bowel and bladder function in fetal ovine myelomeningocele repair.Journal of pediatric surgery · 2022Article
- Urodynamic characteristics of neurogenic bladder in newborns with myelomeningocele and refinement of the definition of bladder hostility: Findings from the UMPIRE multi-center study.Journal of pediatric urology · 2021Article
- Percutaneous fetoscopic spina bifida repair: effect on ambulation and need for postnatal cerebrospinal fluid diversion and bladder catheterization.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2021Article
- Practice-changing publications: Pediatric urology - focus on treatment of spina bifida.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2021Article
- Contractile and Structural Properties of Detrusor from Children with Neurogenic Lower Urinary Tract Dysfunction.Biology · 2021Article
- Fetal myelomeningocele repair: a narrative review of the history, current controversies and future directions.Translational pediatrics · 2021Review
- Fetal surgery for spina bifida in Zurich: results from 150 cases.Pediatric surgery international · 2021Article
- Urological Outcome after Fetal Spina Bifida Repair: Data from the Zurich Cohort.Fetal diagnosis and therapy · 2020Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundA substudy of the Management of Myelomeningocele Study evaluating urological outcomes was conducted.
methodsPregnant women diagnosed with fetal myelomeningocele were randomly assigned to either prenatal or standard postnatal surgical repair. The substudy included patients randomly assigned after April 18, 2005. The primary outcome was defined in their children as death or the need for clean intermittent catheterization (CIC) by 30 months of age characterized by prespecified criteria. Secondary outcomes included bladder and kidney abnormalities observed by urodynamics and renal/bladder ultrasound at 12 and 30 months, which were analyzed as repeated measures.
resultsOf the 115 women enrolled in the substudy, the primary outcome occurred in 52% of children in the prenatal surgery group and 66% in the postnatal surgery group (relative risk [RR]: 0.78; 95% confidence interval [CI]: 0.57-1.07). Actual rates of CIC use were 38% and 51% in the prenatal and postnatal surgery groups, respectively (RR: 0.74; 95% CI: 0.48-1.12). Prenatal surgery resulted in less trabeculation (RR: 0.39; 95% CI: 0.19-0.79) and fewer cases of open bladder neck on urodynamics (RR: 0.61; 95% CI: 0.40-0.92) after adjustment by child's gender and lesion level. The difference in trabeculation was confirmed by ultrasound.
conclusionsPrenatal surgery did not significantly reduce the need for CIC by 30 months of age but was associated with less bladder trabeculation and open bladder neck. The implications of these findings are unclear now, but support the need for long-term urologic follow-up of patients with myelomeningocele regardless of type of surgical repair.
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