ArticleMolecular and cellular biology2015
PAK1 and CtBP1 Regulate the Coupling of Neuronal Activity to Muscle Chromatin and Gene Expression.
Article in Molecular and cellular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- CtBP1 sustains activity-dependent muscle properties and dampens synaptic, contractile and metabolic changes triggered by denervation.Skeletal muscle · 2026Article
- CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I.Skeletal muscle · 2024Article
- Simple Methods for Permanent or Transient Denervation in Mouse Sciatic Nerve Injury Models.Bio-protocol · 2022Article
- Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers.Nature communications · 2020Article
- Coordinated dysregulation of cancer progression by the HER family and p21-activated kinases.Cancer metastasis reviews · 2020Review
- Prediction of the Secretome and the Surfaceome: A Strategy to Decipher the Crosstalk between Adipose Tissue and Muscle during Fetal Growth.International journal of molecular sciences · 2020Article
- H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles.Nucleic acids research · 2020Article
- mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4.Nature communications · 2019Article
- Late-onset megaconial myopathy in mice lacking group I Paks.Skeletal muscle · 2019Article
- Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy.Journal of cachexia, sarcopenia and muscle · 2018Article
- Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle.Journal of visualized experiments : JoVE · 2017Article
- Signaling coupled epigenomic regulation of gene expression.Oncogene · 2017Review
- Review
- Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.Molecular and cellular biology · 2017Article
- Traumatic muscle fibrosis: From pathway to prevention.The journal of trauma and acute care surgery · 2017Review
- Report on the 3rd Ottawa International Conference on Neuromuscular Biology, Disease and Therapy - September 24-26, 2015, Ottawa, Canada.Journal of neuromuscular diseases · 2016Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylcholine receptor (AChR) expression in innervated muscle is limited to the synaptic region. Neuron-induced electrical activity participates in this compartmentalization by promoting the repression of AChR expression in the extrasynaptic regions. Here, we show that the corepressor CtBP1 (C-terminal binding protein 1) is present on the myogenin promoter together with repressive histone marks. shRNA-mediated downregulation of CtBP1 expression is sufficient to derepress myogenin and AChR expression in innervated muscle. Upon denervation, CtBP1 is displaced from the myogenin promoter and relocates to the cytoplasm, while repressive histone marks are replaced by activating ones concomitantly to the activation of myogenin expression. We also observed that upon denervation the p21-activated kinase 1 (PAK1) expression is upregulated, suggesting that phosphorylation by PAK1 may be involved in the relocation of CtBP1. Indeed, preventing CtBP1 Ser158 phosphorylation induces CtBP1 accumulation in the nuclei and abrogates the activation of myogenin and AChR expression. Altogether, these findings reveal a molecular mechanism to account for the coordinated control of chromatin modifications and muscle gene expression by presynaptic neurons via a PAK1/CtBP1 pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.