Evidence map›Paper›PMID 26416864›Full record

ArticleAntimicrobial agents and chemotherapy2015

The Pathogen-Derived Aminoglycoside Resistance 16S rRNA Methyltransferase NpmA Possesses Dual m1A1408/m1G1408 Specificity.

Natalia Zelinskaya, Marta A Witek, Graeme L Conn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. 50S subunit recognition and modification by theProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natalia ZelinskayaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Marta A WitekDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Graeme L ConnDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA gconn@emory.edu.ORCID http://orcid.org/0000-0002-2419-380X

Funding

RNA modification and antibiotic resistanceR01AI088025 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Christine M Dunham · 2010 to 2026
$7.9M
NIAID NIH HHS R01 AI088025NIAID NIH HHS R01-AI088025
6 · The paper itself

Abstract

Chemical modification of 16S rRNA can confer exceptionally high-level resistance to a diverse set of aminoglycoside antibiotics. Here, we show that the pathogen-derived enzyme NpmA possesses dual m(1)A1408/m(1)G1408 activity, an unexpected property apparently unique among the known aminoglycoside resistance 16S rRNA (m(1)A1408) methyltransferases. Although the biological significance of this activity remains to be determined, such mechanistic variation in enzymes acquired by pathogens has significant implications for development of inhibitors of these emerging resistance determinants.

Indexed as

ActinobacteriaAminoglycosidesAnti-Bacterial AgentsBacterial ProteinsBase SequenceDrug Resistance, BacterialEscherichia coliEscherichia coli ProteinsEubacterialesGene ExpressionKineticsMethylationMethyltransferasesMolecular Sequence DataNucleic Acid ConformationRNA, Ribosomal, 16SAminoglycosidesAnti-Bacterial AgentsBacterial ProteinsEscherichia coli ProteinsMethyltransferasesNpmA protein, E coliRNA, Ribosomal, 16S

Identifiers

PMID26416864
PMCPMC4649141

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.