ArticleNature2015
Binding of dinitrogen to an iron-sulfur-carbon site.
Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 261 citations in OpenAlex.
- Reversible NNational science review · 2026Article
- A Synthetic Iron Model of Carbon-Sulfur Bond Activation by the Nitrogenase-Family Enzyme Methylthio-Alkane Reductase.Journal of the American Chemical Society · 2026Article
- Lattice O-O ligands in Fe-incorporated hydroxides enhance water oxidation electrocatalysis.Nature chemistry · 2025Article
- Molybdenum-Iron-Sulfur Cluster with a Bridging Carbide Ligand as a Partial FeMoco Model: CO Activation, EPR Studies, and Bonding Insight.Journal of the American Chemical Society · 2025Article
- Article
- Low-Valent Transition Metalate Anions in Synthesis, Small Molecule Activation, and Catalysis.Chemical reviews · 2024Review
- Understanding the Electronic Structure Basis for NInorganic chemistry · 2023Article
- Sulfur-Ligated [2Fe-2C] Clusters as Synthetic Model Systems for Nitrogenase.Inorganic chemistry · 2023Article
- Dinitrogen cleavage and hydrogenation to ammonia with a uranium complex.National science review · 2023Article
- Terminal NChemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Article
- Bonding and stability of dinitrogen-bonded donor base-stabilized Si(0)/Ge(0) species [(cAACRSC advances · 2022Article
- Iron Complexes of a Proton-Responsive SCS Pincer Ligand with a Sensitive Electronic Structure.Inorganic chemistry · 2022Article
- Estimations of FeRSC advances · 2022Article
- EDA-NOCV Calculation for Efficient NACS omega · 2021Article
- Estimations of Fe-NACS omega · 2021Article
- Partial synthetic models of FeMoco with sulfide and carbyne ligands: Effect of interstitial atom in nitrogenase active site.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Dinitrogen binding and activation at a molybdenum-iron-sulfur cluster.Nature chemistry · 2021Article
- Synthesis and Reactivity of Iron Complexes with a Biomimetic SCS Pincer Ligand.Inorganic chemistry · 2021Article
- Cleavage of cluster iron-sulfide bonds in cyclophane-coordinated FeDalton transactions (Cambridge, England : 2003) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Nitrogenases are the enzymes by which certain microorganisms convert atmospheric dinitrogen (N2) to ammonia, thereby providing essential nitrogen atoms for higher organisms. The most common nitrogenases reduce atmospheric N2 at the FeMo cofactor, a sulfur-rich iron-molybdenum cluster (FeMoco). The central iron sites that are coordinated to sulfur and carbon atoms in FeMoco have been proposed to be the substrate binding sites, on the basis of kinetic and spectroscopic studies. In the resting state, the central iron sites each have bonds to three sulfur atoms and one carbon atom. Addition of electrons to the resting state causes the FeMoco to react with N2, but the geometry and bonding environment of N2-bound species remain unknown. Here we describe a synthetic complex with a sulfur-rich coordination sphere that, upon reduction, breaks an Fe-S bond and binds N2. The product is the first synthetic Fe-N2 complex in which iron has bonds to sulfur and carbon atoms, providing a model for N2 coordination in the FeMoco. Our results demonstrate that breaking an Fe-S bond is a chemically reasonable route to N2 binding in the FeMoco, and show structural and spectroscopic details for weakened N2 on a sulfur-rich iron site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.