ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Progressing a human embryonic stem-cell-based regenerative medicine therapy towards the clinic.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Trial
- Multi-omics insights into bone tissue injury and healing: bridging orthopedic trauma and regenerative medicine.Burns & trauma · 2025Review
- Improved Method for Dental Pulp Stem Cell Preservation and Its Underlying Cell Biological Mechanism.Cells · 2023Article
- Applications of 3D printed bone tissue engineering scaffolds in the stem cell field.Regenerative therapy · 2021Review
- GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells.Stem cell research & therapy · 2020Article
- Building an Artificial Stem Cell Niche: Prerequisites for Future 3D-Formation of Inner Ear Structures-Toward 3D Inner Ear Biotechnology.Anatomical record (Hoboken, N.J. : 2007) · 2020Review
- Pluripotent Stem Cells for the Treatment of Retinal Degeneration: Current Strategies and Future Directions.Frontiers in cell and developmental biology · 2020Review
- Review
- hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson's Disease.Cell reports · 2019Article
- Advances in stem cell research and therapeutic development.Nature cell biology · 2019Review
- Stem Cell Treatment in Retinal Diseases: Recent Developments.Turkish journal of ophthalmology · 2018Review
- Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review.Restorative neurology and neuroscience · 2018Review
- Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage.Stem cells translational medicine · 2017Article
- A basis for comparison: sensitive authentication of stem cell derived RPE using physiological responses of intact RPE monolayers.Stem cell and translational investigation · 2017Article
- Response to: Dittrich et al.: Non-Embryo-Destructive Extraction of Pluripotent Embryonic Stem Cells - Overlooked Legal Prohibitions, Professional Legal Consequences and Inconsistencies in Patent Law.Geburtshilfe und Frauenheilkunde · 2016Article
- DNA Transposition at Work.Chemical reviews · 2016Review
- Laminin modification subretinal bio-scaffold remodels retinal pigment epithelium-driven microenvironment in vitro and in vivo.Oncotarget · 2016Article
- A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells.Stem cell research & therapy · 2016Article
- Activation of proHGF by St14 induces mouse embryonic stem cell differentiation.Protein & cell · 2016Article
- hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation.Experimental neurology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Since the first publication of the derivation of human embryonic stem cells in 1998, there has been hope and expectation that this technology will lead to a wave of regenerative medicine therapies with the potential to revolutionize our approach to managing certain diseases. Despite significant resources in this direction, the path to the clinic for an embryonic stem-cell-based regenerative medicine therapy has not proven straightforward, though in the past few years progress has been made. Here, with a focus upon retinal disease, we discuss the current status of the development of such therapies. We also highlight some of our own experiences of progressing a retinal pigment epithelium cell replacement therapy towards the clinic.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.