ArticleJournal of neuroscience methods2016
Development and initial evaluation of a semi-automatic approach to assess perivascular spaces on conventional magnetic resonance images.
Article in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Comparison of T1w, T2w, and T1w/T2w MRI methods for perivascular space quantification.Neuroradiology · 2026Article
- A comprehensive framework for automated segmentation of perivascular spaces in brain MRI with the nnU-Net.Neuroradiology · 2026Article
- Article
- Assessment of the glymphatic function in children with attention-deficit/hyperactivity disorder.European radiology · 2024Article
- Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures.Fluids and barriers of the CNS · 2023Article
- Correlation between enlarged perivascular space and brain white matter hyperintensities in patients with recent small subcortical infarct.Brain and behavior · 2023Article
- Effect of cerebral small vessel disease on cognitive impairment in Parkinson's disease.Acta neurologica Belgica · 2023Article
- Deep Learning Based Detection of Enlarged Perivascular Spaces on Brain MRI.Neuroimage. Reports · 2023Article
- Automated Methods for Detecting and Quantitation of Enlarged Perivascular spaces on MRI.Journal of magnetic resonance imaging : JMRI · 2023Review
- Brain Enlarged Perivascular Spaces as Imaging Biomarkers of Cerebrovascular Disease: A Clinical Narrative Review.Journal of the American Heart Association · 2022Review
- Imaging perivascular space structure and function using brain MRI.NeuroImage · 2022Review
- MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau.Frontiers in psychiatry · 2022Article
- Enlarged Perivascular Spaces Are Negatively Associated With Montreal Cognitive Assessment Scores in Older Adults.Frontiers in neurology · 2022Article
- A critical guide to the automated quantification of perivascular spaces in magnetic resonance imaging.Frontiers in neuroscience · 2022Review
- Perivascular spaces as a marker of disease severity and neurodegeneration in patients with behavioral variant frontotemporal dementia.Frontiers in neuroscience · 2022Article
- Automatic quantification of perivascular spaces in T2-weighted images at 7 T MRI.Cerebral circulation - cognition and behavior · 2022Article
- Associations Between Vascular Risk Factors and Perivascular Spaces in Adults with Intact Cognition, Mild Cognitive Impairment, and Dementia.Journal of Alzheimer's disease : JAD · 2022Article
- Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology.Neuroradiology · 2021Review
- 3D Segmentation of Perivascular Spaces on T1-Weighted 3 Tesla MR Images With a Convolutional Autoencoder and a U-Shaped Neural Network.Frontiers in neuroinformatics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposePerivascular spaces (PVS) are associated with ageing, cerebral small vessel disease, inflammation and increased blood brain barrier permeability. Most studies to date use visual rating scales to assess PVS, but these are prone to observer variation.
methodsWe developed a semi-automatic computational method that extracts PVS on bilateral ovoid basal ganglia (BG) regions on intensity-normalised T2-weighted magnetic resonance images. It uses Analyze™10.0 and was applied to 100 mild stroke patients' datasets. We used linear regression to test association between BGPVS count, volume and visual rating scores; and between BGPVS count & volume, white matter hyperintensity (WMH) rating scores (periventricular: PVH; deep: DWMH) & volume, atrophy rating scores and brain volume.
resultsIn the 100 patients WMH ranged from 0.4 to 119ml, and total brain tissue volume from 0.65 to 1.45l. BGPVS volume increased with BGPVS count (67.27, 95%CI [57.93 to 76.60], p<0.001). BGPVS count was positively associated with WMH visual rating (PVH: 2.20, 95%CI [1.22 to 3.18], p<0.001; DWMH: 1.92, 95%CI [0.99 to 2.85], p<0.001), WMH volume (0.065, 95%CI [0.034 to 0.096], p<0.001), and whole brain atrophy visual rating (1.01, 95%CI [0.49 to 1.53], p<0.001). BGPVS count increased as brain volume (as % of ICV) decreased (-0.33, 95%CI [-0.53 to -0.13], p=0.002). COMPARISON WITH EXISTING
methodBGPVS count and volume increased with the overall increase of BGPVS visual scores (2.11, 95%CI [1.36 to 2.86] for count and 0.022, 95%CI [0.012 to 0.031] for volume, p<0.001). Distributions for PVS count and visual scores were also similar.
conclusionsThis semi-automatic method is applicable to clinical protocols and offers quantitative surrogates for PVS load. It shows good agreement with a visual rating scale and confirmed that BGPVS are associated with WMH and atrophy measurements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.