ArticleBMC evolutionary biology2015
In silico evolution of diauxic growth.
Article in BMC evolutionary biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Dynamic metabolic adaptation can promote species coexistence in competitive microbial communities.PLoS computational biology · 2020Article
- Pseudomonad reverse carbon catabolite repression, interspecies metabolite exchange, and consortial division of labor.Cellular and molecular life sciences : CMLS · 2020Review
- CcpA-Dependent Carbon Catabolite Repression Regulates Fructooligosaccharides Metabolism inFrontiers in microbiology · 2018Article
- A non-linear model of hydrogen production byBiotechnology for biofuels · 2018Article
- Modelling microbial metabolic rewiring during growth in a complex medium.BMC genomics · 2016Article
- The lag-phase during diauxic growth is a trade-off between fast adaptation and high growth rate.Scientific reports · 2016Article
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Authors and funding
1 author.
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Abstract
backgroundThe glucose effect is a well known phenomenon whereby cells, when presented with two different nutrients, show a diauxic growth pattern, i.e. an episode of exponential growth followed by a lag phase of reduced growth followed by a second phase of exponential growth. Diauxic growth is usually thought of as a an adaptation to maximise biomass production in an environment offering two or more carbon sources. While diauxic growth has been studied widely both experimentally and theoretically, the hypothesis that diauxic growth is a strategy to increase overall growth has remained an unconfirmed conjecture.
methodsHere, we present a minimal mathematical model of a bacterial nutrient uptake system and metabolism. We subject this model to artificial evolution to test under which conditions diauxic growth evolves.
resultsAs a result, we find that, indeed, sequential uptake of nutrients emerges if there is competition for nutrients and the metabolism/uptake system is capacity limited. DISCUSSION: However, we also find that diauxic growth is a secondary effect of this system and that the speed-up of nutrient uptake is a much larger effect. Notably, this speed-up of nutrient uptake coincides with an overall reduction of efficiency.
conclusionsOur two main conclusions are: (i) Cells competing for the same nutrients evolve rapid but inefficient growth dynamics. (ii) In the deterministic models we use here no substantial lag-phase evolves. This suggests that the lag-phase is a consequence of stochastic gene expression.
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