ReviewExpert review of neurotherapeutics2015
Management of epilepsy during pregnancy.
Review in Expert review of neurotherapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Population Pharmacokinetics of Levetiracetam: A Systematic Review.Clinical pharmacokinetics · 2021Pooled it
- Severe maternal morbidity in pregnancies complicated by maternal seizure disorder.Pregnancy (Hoboken, N.J.) · 2026Article
- Prenatal antiseizure drug exposure and risk of neurodevelopmental disorders in children: population based cohort study.BMJ (Clinical research ed.) · 2026Article
- Effects of Antiseizure Medications on Second-Trimester Prenatal Screening Test Parameters: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Empiric dosing strategies to predict lamotrigine concentrations during pregnancy.Pharmacotherapy · 2023Article
- Managing Antiseizure Medications in Pregnancy: Is Earlier and More Frequent Monitoring Better?Neurology. Clinical practice · 2023Article
- Strategies for the Emergency Treatment of Pregnant Women with Neurological Symptoms during the COVID-19 Pandemic.Aging and disease · 2023Article
- News in pharmacology for the main medical pathologies of gestation.Frontiers in pharmacology · 2023Review
- Comparative analysis of three decades' experience in the management of pregnant women with epilepsy: a real-life scenario.Frontiers in neurology · 2023Article
- Management of Anti-Seizure Medications during Pregnancy: Advancements in The Past Decade.Pharmaceutics · 2022Review
- ATP-binding cassette (ABC) drug transporters in the developing blood-brain barrier: role in fetal brain protection.Cellular and molecular life sciences : CMLS · 2022Review
- Pregnancy and the Control of Epileptic Seizures: A Review.Neurology and therapy · 2021Review
- Anaesthesia and neurological disorders in pregnancy.BJA education · 2021Review
- Epilepsy management in pregnant HIV+ women in sub-Saharan Africa, clinical aspects to consider: a scoping review.BMC medicine · 2020Article
- Antiepileptic Drugs Usage in Pregnant Women with Epilepsy in Saudi Arabia.Journal of epilepsy research · 2019Article
- Treatment With Antipsychotics in Pregnancy: Changes in Drug Disposition.Clinical pharmacology and therapeutics · 2018Article
- Is neurostimulation through the vagal nerve safe during pregnancy?Epilepsy research · 2017Article
- Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition.PloS one · 2017Article
- Neurological Complications of Pregnancy.Current neurology and neuroscience reports · 2016Review
- Women with epilepsy: clinically relevant issues.Functional neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Over a million women with epilepsy are of childbearing age in the USA and require careful consideration of not only type of antiepileptic drug (AED) but also dosage, in the event of a planned or unplanned pregnancy. Careful selection of AEDs can lower the potential adverse effects of AEDs while maintaining seizure control for the health of not only on the patient, the mother, but also the unborn fetus. The number of treatment options has increased significantly in the last 20 years and remarkable progress has been made in characterizing the risks AEDs pose to pregnant women and fetuses. There are now robust data on teratogenesis, a growing body of data on neonatal/obstetrical outcomes and on neurodevelopmental problems associated with each AED, and some data about seizure control during pregnancy. Based on clinical evidence so far, levetiracetam and lamotrigine have emerged as the safest during pregnancy, although others may also be suitable. Despite being a common belief, not all polytherapy combinations may be detrimental, especially when avoiding valproate and topiramate. Here, we review the available clinical research, highlighting recent findings and provide thoughts for future directions in the field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.