ArticleHuman brain mapping2015
Neural responses to kindness and malevolence differ in illness and recovery in women with anorexia nervosa.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Genetic polymorphisms and their association with neurobiological and psychological factors in anorexia nervosa: a systematic review.Frontiers in psychology · 2024Pooled it
- Endogenous opioid receptors and the feast or famine of maladaptive feeding.Nature communications · 2025Review
- Diminished Adaptation, Satisfaction, and Neural Responses to Advantageous Social Signals in Anorexia Nervosa and Bulimia Nervosa.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Interpersonal attribution bias and social evaluation in adolescent eating disorders.European eating disorders review : the journal of the Eating Disorders Association · 2023Article
- Social Processing in Eating Disorders: Neuroimaging Paradigms and Research Domain Organizational Constructs.Current psychiatry reports · 2022Review
- Neural processes related to negative self-concept in adult and adolescent anorexia nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2022Article
- Aberrant neural representation of food stimuli in women with acute anorexia nervosa predicts treatment outcome and is improved in weight restored individuals.Translational psychiatry · 2021Article
- Qualitative patient experiences from the Self-Blame and Perspective-Taking Intervention for eating disorders.Journal of eating disorders · 2021Article
- Structural brain differences in recovering and weight-recovered adult outpatient women with anorexia nervosa.Journal of eating disorders · 2021Article
- The emotional face of anorexia nervosa: The neural correlates of emotional processing.Human brain mapping · 2021Article
- The influence of homeostatic mechanisms on neural regulation of food craving in anorexia nervosa.Psychological medicine · 2021Article
- The Mediator Effect of Personality on the Relationship Between Symptomatic Impairment and Treatment Outcome in Eating Disorders.Frontiers in psychology · 2021Article
- Role of the right temporoparietal junction in intergroup bias in trust decisions.Human brain mapping · 2020Article
- Strengthened Default Mode Network Activation During Delay Discounting in Adolescents with Anorexia Nervosa After Partial Weight Restoration: A Longitudinal fMRI Study.Journal of clinical medicine · 2020Article
- A review of neuroeconomic gameplay in psychiatric disorders.Molecular psychiatry · 2020Review
- Neural Signatures of Gender Differences in Interpersonal Trust.Frontiers in human neuroscience · 2020Article
- Neural Processing of Disorder-Related Stimuli in Patients with Anorexia Nervosa: A Narrative Review of Brain Imaging Studies.Journal of clinical medicine · 2019Review
- Treatment Utilization and Medical Problems in a Community Sample of Adult Women With Anorexia Nervosa.Frontiers in psychology · 2019Article
- A Transdiagnostic Perspective on Social Anhedonia.Frontiers in psychiatry · 2019Review
- Recent advances in understanding anorexia nervosa.F1000Research · 2019Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
In anorexia nervosa, problems with social relationships contribute to illness, and improvements in social support are associated with recovery. Using the multiround trust game and 3T MRI, we compare neural responses in a social relationship in three groups of women: women with anorexia nervosa, women in long-term weight recovery from anorexia nervosa, and healthy comparison women. Surrogate markers related to social signals in the game were computed each round to assess whether the relationship was improving (benevolence) or deteriorating (malevolence) for each subject. Compared with healthy women, neural responses to benevolence were diminished in the precuneus and right angular gyrus in both currently-ill and weight-recovered subjects with anorexia, but neural responses to malevolence differed in the left fusiform only in currently-ill subjects. Next, using a whole-brain regression, we identified an office assessment, the positive personalizing bias, that was inversely correlated with neural activity in the occipital lobe, the precuneus and posterior cingulate, the bilateral temporoparietal junctions, and dorsal anterior cingulate, during benevolence for all groups of subjects. The positive personalizing bias is a self-report measure that assesses the degree with which a person attributes positive experiences to other people. These data suggest that problems in perceiving kindness may be a consistent trait related to the development of anorexia nervosa, whereas recognizing malevolence may be related to recovery. Future work on social brain function, in both healthy and psychiatric populations, should consider positive personalizing biases as a possible marker of neural differences related to kindness perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.