Evidence map›Paper›PMID 26416024›Full record

ArticleOrganic & biomolecular chemistry2016

Increased duplex stabilization in porphyrin-LNA zipper arrays with structure dependent exciton coupling.

Daniel G Singleton, Rohanah Hussain, Giuliano Siligardi, Pawan Kumar, Patrick J Hrdlicka, Nina Berova, Eugen Stulz

Open access · hybridAbstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Nanoarchitectonics with Porphyrin Functionalized DNA.Accounts of chemical research · 2017
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Daniel G SingletonSchool of Chemistry and Institute for Life Sciences, University of Southampton, Highfield, Southampton, SO17 1BJ, UK. est@soton.ac.uk.
Rohanah Hussain
Giuliano Siligardi
Pawan Kumar
Patrick J Hrdlicka
Nina Berova
Eugen Stulz
University of Idaho · USUniversity of Southampton · GBColumbia University · USDiamond Light Source · GBOxfam · GB

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

Porphyrins were attached to LNA uridine building blocks via rigid 5-acetylene or more flexible propargyl-amide linkers and incorporated into DNA strands. The systems show a greatly increased thermodynamic stability when using as little as three porphyrins in a zipper arrangement. Thermodynamic analysis reveals clustering of the strands into more ordered duplexes with both greater negative ΔΔS and ΔΔH values, and less ordered duplexes with small positive ΔΔS differences, depending on the combination of linkers used. The exciton coupling between the porphyrins is dependent on the flanking DNA sequence in the single stranded form, and on the nature of the linker between the nucleobase and the porphyrin in the double stranded form; it is, however, also strongly influenced by intermolecular interactions. This system is suitable for the formation of stable helical chromophore arrays with sequence and structure dependent exciton coupling.

Indexed as

Circular DichroismMolecular StructureOligonucleotidesOrganometallic CompoundsPorphyrinsThermodynamicsZinclocked nucleic acidOligonucleotidesOrganometallic CompoundsPorphyrinsZinc

Identifiers

PMID26416024
PMCPMC4766578
OpenAlexW1791746369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.