ArticleLasers in medical science2015
Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis.
Article in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Standardized Photobiomodulation Dosimetry Targeting the Base of Calvarial Critical-Sized Defects for Bone Regeneration: A Preclinical RCT Comparing Flattop vs. Gaussian Beam Profiles, with or Without Bio-OssJournal of functional biomaterials · 2026Article
- Photobiomodulation of alveolar bone healing in rats with low-level laser and light emitting diode therapy.Lasers in medical science · 2025Article
- High- and Low-Level Laser Therapy for the Treatment of Orthopedic Pain: A Systematic Review.Journal of lasers in medical sciences · 2025Review
- Bone Regeneration of Rat Critical-Sized Calvarial Defects by the Combination of Photobiomodulation and Adipose-Derived Mesenchymal Stem Cells.Journal of lasers in medical sciences · 2024Article
- Review
- Tissue Bioengineering with Fibrin Scaffolds and Deproteinized Bone Matrix Associated or Not with the Transoperative Laser Photobiomodulation Protocol.Molecules (Basel, Switzerland) · 2023Article
- Assessment of Photosensitizer Concentration Effects on the Efficacy of Photodynamic Therapy.Journal of lasers in medical sciences · 2023Article
- Use of Photobiomodulation Combined with Fibrin Sealant and Bone Substitute Improving the Bone Repair of Critical Defects.Polymers · 2022Article
- Texturized P(VDF-TrFE)/BT membrane enhances bone neoformation in calvaria defects regardless of the association with photobiomodulation therapy in ovariectomized rats.Clinical oral investigations · 2022Article
- Bone Neoformation Induced by Low-Level Laser and Methylene Blue Suggests Early Ossification in Rats.Journal of lasers in medical sciences · 2022Article
- Marine collagen scaffolds and photobiomodulation on bone healing process in a model of calvaria defects.Journal of bone and mineral metabolism · 2020Article
- Effects of photobiomodulation therapy in the integration of skin graft in rats.Lasers in medical science · 2020Article
- Photobiomodulation guided healing in a sub-critical bone defect in calvarias of rats.Laser therapy · 2019Article
- Bioglass/PLGA associated to photobiomodulation: effects on the healing process in an experimental model of calvarial bone defect.Journal of materials science. Materials in medicine · 2019Article
- Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2019Article
- The influence of LLLT applied on applied on calvarial defect in rats under effect of cigarette smoke.Journal of applied oral science : revista FOB · 2019Article
- Low-level laser irradiation modulates the proliferation and the osteogenic differentiation of bone marrow mesenchymal stem cells under healthy and inflammatory condition.Lasers in medical science · 2019Article
- Association of Bioglass/Collagen/Magnesium composites and low level irradiation: effects on bone healing in a model of tibial defect in rats.Laser therapy · 2018Article
- Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study.Journal of applied oral science : revista FOB · 2018Article
- Study on mechanism of release oxygen by photo-excited hemoglobin in low-level laser therapy.Lasers in medical science · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
This study evaluated the morphological changes produced by LLLT on the initial stages of bone healing and also studied the pathways that stimulate the expression of genes related to bone cell proliferation and differentiation. One hundred Wistar rats were divided into control and treated groups. Noncritical size bone defects were surgically created at the upper third of the tibia. Laser irradiation (Ga-Al-As laser 830 nm, 30 mW, 94 s, 2.8 J) was performed for 1, 2, 3, 5, and 7 sessions. Histopathology revealed that treated animals produced increased amount of newly formed bone at the site of the injury. Moreover, microarray analysis evidenced that LLLT produced a significant increase in the expression TGF-β, BMP, FGF, and RUNX-2 that could stimulate osteoblast proliferation and differentiation, which may be related to improving the deposition of newly formed bone at the site of the injury. Thus, it is possible to conclude that LLLT improves bone healing by producing a significant increase in the expression of osteogenic genes.
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