Evidence map›Paper›PMID 26415887›Full record

ReviewLipids in health and disease2015

The role of fatty acids in insulin resistance.

Barry Sears, Mary Perry

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lipids in health and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 274 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 7 pooled it
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

274 citing papers in PubMed, 7 syntheses or guidelines pooled it, 537 citations in OpenAlex.

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214 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Barry SearsInflammation Research Foundation, 200 Corporate Place, Peabody, MA, 01960, USA. BSears@drsears.com.
Mary PerryInflammation Research Foundation, 200 Corporate Place, Peabody, MA, 01960, USA. MPerry@zoneliving.com.
Inflammation Research Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin resistance is a multi-faceted disruption of the communication between insulin and the interior of a target cell. The underlying cause of insulin appears to be inflammation that can either be increased or decreased by the fatty acid composition of the diet. However, the molecular basis for insulin resistance can be quite different in various organs. This review deals with various types of inflammatory inputs mediated by fatty acids, which affect the extent of insulin resistance in various organs.

Indexed as

DietInsulin ResistanceAdipose TissueDietary FatsFatty AcidsGene Expression RegulationHumansHypothalamusI-kappa B KinaseInflammationInsulinLiverMAP Kinase Kinase 4Muscle, SkeletalObesityTumor Necrosis Factor-alphaDietary FatsFatty AcidsI-kappa B KinaseInsulinMAP Kinase Kinase 4Tumor Necrosis Factor-alpha

Identifiers

PMID26415887
PMCPMC4587882
OpenAlexW2104754537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.