ArticleAging clinical and experimental research2016
Replication study of the vitamin D receptor (VDR) genotype association with skeletal muscle traits and sarcopenia.
Article in Aging clinical and experimental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review.Nutrients · 2021Pooled it
- Effect of vitamin D supplementation on upper and lower limb muscle strength and muscle power in athletes: A meta-analysis.PloS one · 2019Pooled it
- Vitamin D Supplementation in Nursing Home Residents: Randomized Single Cholecalciferol Loading Protocol vs. Individualized Loading Dose Regimen.The journal of nutrition, health & aging · 2017Trial
- A multi-domain algorithm towards precision nutrition: integrating genetic risk scores and phenotypic diversity in the elderly, the MyFOOD4Senior study.Genes & nutrition · 2026Article
- Vitamin D Receptor rs731236 Polymorphism Modulates Cancer Cachexia Susceptibility and Overall Survival: A Real-World Study on Context-Dependent Vitamin D Signalling.International journal of molecular sciences · 2026Article
- Review
- Article
- Exploring the impact of vitamin D-related genetic variants on muscular fitness changes in middle-aged and older adults in Kosovo.Frontiers in public health · 2025Article
- Identification and Characterization of Genomic Predictors of Sarcopenia and Sarcopenic Obesity Using UK Biobank Data.Nutrients · 2023Article
- Poor Physical Capacity Combined With High Body Fat Percentage as an Independent Risk Factor for Incident Hypertension in Chinese Suburb-Dwelling Older Adults.Frontiers in public health · 2022Article
- The association between vitamin D receptor polymorphisms and tissue-specific insulin resistance in human obesity.International journal of obesity (2005) · 2021Article
- Relationship of vitamin D receptor gene polymorphism with sarcopenia and muscle traits based on propensity score matching.Journal of clinical laboratory analysis · 2020Article
- Pilot Study on Genetic Associations With Age-Related Sarcopenia.Frontiers in genetics · 2020Article
- Is it reasonable to ignore vitamin D status for musculoskeletal health?Faculty reviews · 2020Review
- Impact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblasts.Endocrine connections · 2019Article
- Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection.Aging and disease · 2018Article
- Physical Activity and Nutrition INfluences In ageing (PANINI): consortium mission statement.Aging clinical and experimental research · 2018Article
- Myopenia and precision (P4) medicine.Journal of cachexia, sarcopenia and muscle · 2017Article
- Genetic Variant in ACVR2B Is Associated with Lean Mass.Medicine and science in sports and exercise · 2016Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Polymorphisms in the vitamin D receptor (VDR) gene are some of the most studied in relation to skeletal muscle traits and significant associations have been observed by multiple groups. One such paper by our group provided the first evidence of a genetic association with sarcopenia in men, but that finding has yet to be replicated in an independent cohort. In the present study, we examined multiple VDR polymorphisms in relation to skeletal muscle traits and sarcopenia in 864 men and women across the adult age span. In addition to VDR genotypes and haplotypes, measurements of skeletal muscle strength and fat-free mass (FFM) were determined in all subjects and a measure of sarcopenia was calculated. We observed significant associations between Fok1 and Bsm1 genotypes and skeletal muscle strength in men and women, though these associations were modest and no significant associations were observed for these polymorphisms and muscle mass traits nor for Bsm1-Taq1 haplotype with muscle strength. Fok1 FF genotype was associated with an increased the risk of sarcopenia in older women compared to f-allele carriers (1.3-fold higher risk). These results support previous findings that VDR genetic variation appears to impact skeletal muscle strength and risk for sarcopenia but the influence is modest.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.