ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2015
Harmonic motion imaging for abdominal tumor detection and high-intensity focused ultrasound ablation monitoring: an in vivo feasibility study in a transgenic mouse model of pancreatic cancer.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- A Multimodal Ultrasound-Driven Approach for Automated Tumor Assessment With B-Mode and Multi-Frequency Harmonic Motion Images.IEEE transactions on bio-medical engineering · 2026Article
- An optimized multi-task contrastive learning framework for HIFU lesion detection and segmentation.Scientific reports · 2025Article
- Development of a PTV margin for preclinical irradiation of orthotopic pancreatic tumors derived from a well-known recipe for humans.Zeitschrift fur medizinische Physik · 2024Article
- Optimization of the Tracking Beam Sequence in Harmonic Motion Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Harmonic Motion Imaging-Guided Focused Ultrasound Ablation: Comparison of Three Focused Ultrasound Interference Filtering Methods.Ultrasound in medicine & biology · 2024Article
- Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review.Journal of clinical medicine · 2023Review
- Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Mouse Glioblastoma Model.Ultrasound in medicine & biology · 2023Article
- An Efficient and Multi-Focal Focused Ultrasound Technique for Harmonic Motion Imaging.IEEE transactions on bio-medical engineering · 2023Article
- An analytical model of full-field displacement and strain induced by amplitude-modulated focused ultrasound in harmonic motion imaging.Physics in medicine and biology · 2021Article
- Synchronous temperature variation monitoring during ultrasound imaging and/or treatment pulse application: a phantom study.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2021Article
- Harmonic motion imaging of human breast masses: an in vivo clinical feasibility.Scientific reports · 2020Article
- Preclinical Imaging Using Single Track Location Shear Wave Elastography: Monitoring the Progression of Murine Pancreatic Tumor Liver Metastasis In Vivo.IEEE transactions on medical imaging · 2020Article
- Comparison of Displacement Tracking Algorithms for in Vivo Electrode Displacement Elastography.Ultrasound in medicine & biology · 2019Article
- Technical Note: In vivo Young's modulus mapping of pancreatic ductal adenocarcinoma during HIFU ablation using harmonic motion elastography (HME).Medical physics · 2018Article
- Pre-clinical MR elastography: Principles, techniques, and applications.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Review
- Elastographic Assessment of Xenograft Pancreatic Tumors.Ultrasound in medicine & biology · 2017Article
- Article
- Fast lesion mapping during HIFU treatment using harmonic motion imaging guided focused ultrasound (HMIgFUS) in vitro and in vivo.Physics in medicine and biology · 2017Article
- Elasticity mapping of murine abdominal organs in vivo using harmonic motion imaging (HMI).Physics in medicine and biology · 2016Article
- Tumor characterization and treatment monitoring of postsurgical human breast specimens using harmonic motion imaging (HMI).Breast cancer research : BCR · 2016Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Harmonic motion imaging (HMI) is a radiationforce- based elasticity imaging technique that tracks oscillatory tissue displacements induced by sinusoidal ultrasonic radiation force to assess the resulting oscillatory displacement denoting the underlying tissue stiffness. The objective of this study was to evaluate the feasibility of HMI in pancreatic tumor detection and high-intensity focused ultrasound (HIFU) treatment monitoring. The HMI system consisted of a focused ultrasound transducer, which generated sinusoidal radiation force to induce oscillatory tissue motion at 50 Hz, and a diagnostic ultrasound transducer, which detected the axial tissue displacements based on acquired radio-frequency signals using a 1-D cross-correlation algorithm. For pancreatic tumor detection, HMI images were generated for pancreatic tumors in transgenic mice and normal pancreases in wild-type mice. The obtained HMI images showed a high contrast between normal and malignant pancreases with an average peak-to-peak HMI displacement ratio of 3.2. Histological analysis showed that no tissue damage was associated with HMI when it was used for the sole purpose of elasticity imaging. For pancreatic tumor ablation monitoring, the focused ultrasound transducer was operated at a higher acoustic power and longer pulse length than that used in tumor detection to simultaneously induce HIFU thermal ablation and oscillatory tissue displacements, allowing HMI monitoring without interrupting tumor ablation. HMI monitoring of HIFU ablation found significant decreases in the peak-to-peak HMI displacements before and after HIFU ablation with a reduction rate ranging from 15.8% to 57.0%. The formation of thermal lesions after HIFU exposure was confirmed by histological analysis. This study demonstrated the feasibility of HMI in abdominal tumor detection and HIFU ablation monitoring.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.