ArticleCancer cytopathology2016
Cytopathologic diagnosis of oncocytic type intraductal papillary mucinous neoplasm: Criteria and clinical implications of accurate diagnosis.
Article in Cancer cytopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Deciphering pancreatobiliary intraductal oncocytic papillary neoplasms: integrative analysis of histomorphologic patterns, immunophenotypic markers, and emerging molecular biomarkers.World journal of surgical oncology · 2025Review
- MRI findings of pancreatic intraductal oncocytic papillary neoplasm: three case reports and review of literature.Frontiers in medicine · 2025Article
- Liquid-based cytology features of pancreatic acinar cell carcinoma: comparison with other non-ductal neoplasms of the pancreas.Journal of pathology and translational medicine · 2024Article
- Preoperatively diagnosed intraductal oncocytic papillary neoplasm of the pancreas with prominent invasion: a case report.Clinical journal of gastroenterology · 2023Article
- Article
- Characterization and digital spatial deconvolution of the immune microenvironment of intraductal oncocytic papillary neoplasms (IOPN) of the pancreas.Virchows Archiv : an international journal of pathology · 2023Article
- Intraductal oncocytic papillary neoplasm (IOPN): two case reports and review of the literature.Translational cancer research · 2023Article
- Background features in the cytology of pancreatic neoplasms.DEN open · 2022Review
- CD117 Is a Specific Marker of Intraductal Papillary Mucinous Neoplasms (IPMN) of the Pancreas, Oncocytic Subtype.International journal of molecular sciences · 2020Article
- Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.Gastroenterology · 2020Article
- Bile duct involvement by hepatocellular carcinoma: A rare occurrence and poor prognostic indicator in bile duct brushing samples.Cancer cytopathology · 2019Article
- Intraductal Oncocytic Papillary Neoplasms: Clinical-Pathologic Characterization of 24 Cases, With An Emphasis on Associated Invasive Carcinomas.The American journal of surgical pathology · 2019Article
- Pancreatic Cystic Lesions: Pathogenesis and Malignant Potential.Diseases (Basel, Switzerland) · 2018Review
- Oncocytic Type Intraductal Papillary Mucinous Neoplasm of the Pancreas with Unusually Low Mucin Production Mimicking Intraductal Tubulopapillary Neoplasm: A Report of a Case Diagnosed by a Preoperative Endoscopic Biopsy.Internal medicine (Tokyo, Japan) · 2017Article
- Clinicopathological features of intraductal papillary neoplasms of the bile duct: a comparison with intraductal papillary mucinous neoplasm of the pancreas with reference to subtypes.Virchows Archiv : an international journal of pathology · 2017Article
- Intraductal oncocytic papillary neoplasm: a benign hepatic cystic neoplasm.BMJ case reports · 2017Article
- Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas.Virchows Archiv : an international journal of pathology · 2016Article
- Interobserver variability in intraductal papillary mucinous neoplasm subtypes and application of their mucin immunoprofiles.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCytologic findings of pancreatic oncocytic-type intraductal papillary mucinous neoplasms (IPMNs)/intraductal oncocytic papillary neoplasms (IOPNs) are largely unknown.
methodsFive IOPNs encountered by the authors were analyzed.
resultsFour IOPNs were located in the pancreatic head, and 1 was located in the pancreatic body/tail in 2 men and 3 women ages 56 to 84 years (mean age, 66 years). Radiologic diagnoses included pancreatic ductal adenocarcinoma (PDAC) in 2 patients, invasive cancer associated with IPMN in 1 patient, IPMN versus mucinous cystic neoplasm in 1 patient, and cystic mass in 1 patient. Cytologic findings included: hypercellular smears (4 of 5 cases) containing well formed clusters of oncocytic cells (5 of 5 cases) with prominent, slightly eccentric nucleoli (4 of 5 cases), predominantly arranged in sheets/papillary units (5 of 5 cases), with punched-out intercytoplasmic spaces (4 of 5 cases), and with occasional 3-dimensional groups and focal necrosis (3 of 5 cases). The intracytoplasmic mucin and thick extracellular mucin typical of other IPMNs were observed only in 2 cases and were very limited. The mean size on resection was 4.5 cm. Invasion was observed in 3 cases (0.1, 0.3, and 2.0 cm) of tubular-type IPMN. Initial cytologic evaluation was performed by the authors in 4 of 5 cases, which were diagnosed as IOPN (n = 3) and IPMN versus cystic PDAC (n = 1). One case was initially misdiagnosed as PDAC and, on resection, proved to be noninvasive IOPN.
conclusionsCytologic features of IOPNs are classical, similar to their histologic counterparts, and differ significantly from other IPMN subtypes. Because of their highly complex appearance, they are often radiologically misdiagnosed as PDAC; thus, failure to recognize their characteristic features on fine-needle aspiration may lead to inappropriate treatment. Patients with IOPN have an incomparably better prognosis than patients with ordinary PDAC, even when their neoplasms are invasive.
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