ArticleEnvironment international2015
Prenatal DDT and DDE exposure and child IQ in the CHAMACOS cohort.
Article in Environment international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Early exposure to agricultural pesticides and the occurrence of autism spectrum disorder: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022Pooled it
- The microbiota at the interface of environmental toxicants and the brain.Cell metabolism · 2026Review
- Article
- A study protocol for a randomized clinical trial on exposure and effects of pesticides consumption - the PEST-EXPO Brazil study.MethodsX · 2024Article
- Association between pre- and postnatal exposure to endocrine-disrupting chemicals and birth and neurodevelopmental outcomes: an extensive review.Clinical and experimental pediatrics · 2024Article
- Article
- The Contribution of Environmental Science to Mental Health Research: A Scoping Review.International journal of environmental research and public health · 2023Article
- Prenatal and childhood chlordecone exposure, cognitive abilities and problem behaviors in 7-year-old children: the TIMOUN mother-child cohort in Guadeloupe.Environmental health : a global access science source · 2023Article
- Exposure to DDT and DDE and functional neuroimaging in adolescents from the CHAMACOS cohort.Environmental research · 2022Article
- Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study.Autism research : official journal of the International Society for Autism Research · 2022Article
- Prenatal exposure to chemical mixtures and working memory among adolescents.Environmental research · 2022Article
- Neighborhood-Based Socioeconomic Determinants of Cognitive Impairment in Zambian Children With HIV: A Quantitative Geographic Information Systems Approach.Journal of the Pediatric Infectious Diseases Society · 2021Article
- Article
- Gestational Exposure to Organophosphate Pesticides and Longitudinally Assessed Behaviors Related to Attention-Deficit/Hyperactivity Disorder and Executive Function.American journal of epidemiology · 2021Article
- Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression.International journal of molecular sciences · 2021Article
- Organophosphate pesticide exposure during pregnancy and childhood and onset of juvenile delinquency by age 16 years: The CHAMACOS cohort.Environmental research · 2021Article
- A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges.Environmental research · 2020Review
- ImergardInsects · 2020Article
- Prenatal β-Hexachlorocyclohexane (β-HCH) Exposure and 7-Year Child IQ in the CHAMACOS Birth Cohort.Neurotoxicity research · 2020Article
- Bioremediation of Dichlorodiphenyltrichloroethane (DDT)-Contaminated Agricultural Soils: Potential of Two Autochthonous Saprotrophic Fungal Strains.Applied and environmental microbiology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Although banned in most countries, dichlorodiphenyl-trichloroethane (DDT) continues to be used for vector control in some malaria endemic areas. Previous findings from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort study found increased prenatal levels of DDT and its breakdown product dichlorodiphenyl-dichloroethylene (DDE) to be associated with altered neurodevelopment in children at 1 and 2years of age. In this study, we combined the measured maternal DDT/E concentrations during pregnancy obtained for the prospective birth cohort with predicted prenatal DDT and DDE levels estimated for a retrospective birth cohort. Using generalized estimating equation (GEE) and linear regression models, we evaluated the relationship of prenatal maternal DDT and DDE serum concentrations with children's cognition at ages 7 and 10.5years as assessed using the Full Scale Intelligence Quotient (IQ) and 4 subtest scores (Working Memory, Perceptual Reasoning, Verbal Comprehension, and Processing Speed) of the Wechsler Intelligence Scale for Children (WISC). In GEE analyses incorporating both age 7 and 10.5 scores (n=619), we found prenatal DDT and DDE levels were not associated with Full Scale IQ or any of the WISC subscales (p-value>0.05). In linear regression analyses assessing each time point separately, prenatal DDT levels were inversely associated with Processing Speed at age 7years (n=316), but prenatal DDT and DDE levels were not associated with Full Scale IQ or any of the WISC subscales at age 10.5years (n=595). We found evidence for effect modification by sex. In girls, but not boys, prenatal DDE levels were inversely associated with Full Scale IQ and Processing Speed at age 7years. We conclude that prenatal DDT levels may be associated with delayed Processing Speed in children at age 7years and the relationship between prenatal DDE levels and children's cognitive development may be modified by sex, with girls being more adversely affected.
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