ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2015
Different Bla-g T cell antigens dominate responses in asthma versus rhinitis subjects.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Cockroach immunotherapy modulates dominant T-cell responses independent of allergen extract content.The Journal of allergy and clinical immunology · 2025Trial
- The association of allergic sensitization patterns in early childhood with disease manifestations and immunological reactivity at 10 years of age.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Trial
- Effects of Allergen Exposure and Environmental Risk Factors in Schools on Childhood Asthma.Current allergy and asthma reports · 2023Review
- Cockroach allergy: Understanding complex immune responses to develop novel therapies.Molecular immunology · 2023Article
- Heterogeneity of magnitude, allergen immunodominance, and cytokine polarization of cockroach allergen-specific T cell responses in allergic sensitized children.Clinical and translational allergy · 2021Article
- Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens.Journal of visualized experiments : JoVE · 2021Article
- IgE and T Cell Reactivity to a Comprehensive Panel of Cockroach Allergens in Relation to Disease.Frontiers in immunology · 2020Article
- Hydrophobic ligands influence the structure, stability, and processing of the major cockroach allergen Bla g 1.Scientific reports · 2019Article
- Variability in German Cockroach Extract Composition Greatly Impacts T Cell Potency in Cockroach-Allergic Donors.Frontiers in immunology · 2019Article
- Characterization and epitope identification of the T cell response in non-allergic individuals exposed to mouse allergen.The World Allergy Organization journal · 2019Article
- Article
- Determination of a Predictive Cleavage Motif for Eluted Major Histocompatibility Complex Class II Ligands.Frontiers in immunology · 2018Article
- Microbiota epitope similarity either dampens or enhances the immunogenicity of disease-associated antigenic epitopes.PloS one · 2018Article
- Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma.Frontiers in immunology · 2018Article
- Predicting HLA CD4 Immunogenicity in Human Populations.Frontiers in immunology · 2018Article
- Immunoproteomic analysis of house dust mite antigens reveals distinct classes of dominant T cell antigens according to function and serological reactivity.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- New Insights into Cockroach Allergens.Current allergy and asthma reports · 2017Review
- Sequence conservation predicts T cell reactivity against ragweed allergens.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans.PLoS pathogens · 2016Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectiveThe allergenicity of several German cockroach (Bla-g) antigens at the level of IgE responses is well established. However, less is known about the specificity of CD4+ TH responses, and whether differences exist in associated magnitude or cytokine profiles as a function of disease severity.
methodsProteomic and transcriptomic techniques were used to identify novel antigens recognized by allergen-specific T cells. To characterize different TH functionalities of allergen-specific T cells, ELISPOT assays with sets of overlapping peptides covering the sequences of known allergens and novel antigens were employed to measure release of IL-5, IFNγ, IL-10, IL-17 and IL-21.
resultsUsing these techniques, we characterized TH responses in a cohort of adult Bla-g-sensitized subjects, either with (n = 55) or without (n = 17) asthma, and nonsensitized controls (n = 20). T cell responses were detected for ten known Bla-g allergens and an additional ten novel Bla-g antigens, representing in total a 5-fold increase in the number of antigens demonstrated to be targeted by allergen-specific T cells. Responses of sensitized individuals regardless of asthma status were predominantly TH 2, but higher in patients with diagnosed asthma. In asthmatic subjects, Bla-g 5, 9 and 11 were immunodominant, while, in contrast, nonasthmatic-sensitized subjects responded mostly to Bla-g 5 and 4 and the novel antigen NBGA5.
conclusionsAsthmatic and nonasthmatic cockroach-sensitized individuals exhibit similar TH 2-polarized responses. Compared with nonasthmatics, however, asthmatic individuals have responses of higher magnitude and different allergen specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.