ArticleSleep2016
Impaired Sleep Predicts Cognitive Decline in Old People: Findings from the Prospective KORA Age Study.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure.Frontiers in cardiovascular medicine · 2021Pooled it
- Behavioral and Psychological Symptoms that Predict Cognitive Decline or Impairment in Cognitively Normal Middle-Aged or Older Adults: a Meta-Analysis.Neuropsychology review · 2020Pooled it
- Association between mild action tremor and cognition in community dwelling older adults: results from the KORA-Age study.Journal of neurology · 2026Article
- Urban-rural differences and bidirectional association between social participation and cognitive function among Chinese older adults: a 10-year prospective cohort study.Archives of public health = Archives belges de sante publique · 2025Article
- Frailty as a mediator between sleep quality and cognitive impairment among the rural older adults: a cross-sectional study.BMC geriatrics · 2025Article
- Factors associated with cognitive reserve according to education level.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Thirty Risk Factors for Alzheimer's Disease Unified by a Common Neuroimmune-Neuroinflammation Mechanism.Brain sciences · 2023Review
- Association between personality characteristics and sleep quality among Chinese middle-aged and older adults: evidence from China family panel studies.BMC public health · 2023Article
- Interactive association between insomnia symptoms and sleep duration for the risk of dementia-a prospective study in the Swedish National March Cohort.Age and ageing · 2023Article
- A Questionnaire-Based Cross-Sectional Study of Insomnia among Middle-Aged Adults from Greece's Northeastern Fringe, Thrace.Maedica · 2023Article
- Sleep-Related Changes Prior to Cognitive Dysfunction.Current neurology and neuroscience reports · 2023Review
- Association of sleep with cognitive function during retirement transition: the Whitehall II study.Sleep · 2023Article
- Crosswalk between the Mini-Mental State Examination and the Telephone Interview for Cognitive Status (TICS-27/30/40).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Relationship between Resting State Heart Rate Variability and Sleep Quality in Older Adults with Mild Cognitive Impairment.International journal of environmental research and public health · 2021Article
- An exploration of clinical, behavioral, and community factors associated with sleep duration and efficiency among middle-aged Black/African American smokers.Sleep health · 2021Article
- Insomnia in neurological diseases.Neurological research and practice · 2021Article
- Article
- The Role of Sleep Quality, Trait Anxiety and Hypothalamic-Pituitary-Adrenal Axis Measures in Cognitive Abilities of Healthy Individuals.International journal of environmental research and public health · 2020Article
- The effect of insomnia on development of Alzheimer's disease.Journal of neuroinflammation · 2020Review
- Cognitive impairment in a primary healthcare population: a cross-sectional study on the island of Crete, Greece.BMJ open · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo investigate the association between sleep-related characteristics and cognitive change over 3 years of follow up in an aged population.
methodsSleep characteristics and covariates were assessed at baseline in a standardized interview and clinical examination of the population-based KORA Age Study (n = 740, mean age = 75 years). Cognitive score (determined by telephone interview for cognitive status, TICS-m) was recorded at baseline and 3 years later.
resultsAt baseline, 82.83% (n = 613) of participants had normal cognitive status, 13.51% (n = 100) were classified with mild cognitive impairment (MCI), and 3.64% (n = 27) with probable dementia. The effect of three distinct patterns of poor sleep (difficulties initiating [DIS] or maintaining sleep [DMS], daytime sleepiness [DS] or sleep duration) were considered on a change in cognitive score with adjustments for potential confounders in generalized linear regression models. Cognitive decline was more pronounced in individuals with DMS compared to those with no DMS (β = 1.33, 95% CI = 0.41-2.24, P < 0.001). However, the predictive power of DMS was only significant in individuals with normal cognition and not impaired subjects at baseline. Prolonged sleep duration increased the risk for cognitive decline in cognitively impaired elderly (β = 1.86, 95% CI = 0.15-3.57, P = 0.03). Other sleep characteristics (DIS and DS) were not significantly associated with cognitive decline.
conclusionsDMS and long sleep duration were associated with cognitive decline in normal and cognitively impaired elderly, respectively. The identification of impaired sleep quality may offer intervention strategies to deter cognitive decline in the elderly with normal cognitive function.
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