ArticleSleep2016
Cerebral Blood Flow Response to Hypercapnia in Children with Obstructive Sleep Apnea Syndrome.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Sleep-disordered breathing is associated with brain vascular reactivity in spinal cord injury.Neurology · 2019Pooled it
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- Comparison of diffuse correlation spectroscopy analytical models for cerebral blood flow measurements.Journal of biomedical optics · 2025Article
- Noninvasive optical monitoring of cerebral hemodynamics in a preclinical model of neonatal intraventricular hemorrhage.Frontiers in pediatrics · 2025Article
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- Impaired cerebrovascular reactivity in pediatric sickle cell disease using diffuse correlation spectroscopy.Biomedical optics express · 2023Article
- Association Between Disrupted Cerebral Autoregulation and Radiographic Neurologic Injury for Children on Extracorporeal Membrane Oxygenation: A Prospective Pilot Study.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2023Article
- Agreement in cerebrovascular reactivity assessed with diffuse correlation spectroscopy across experimental paradigms improves with short separation regression.Neurophotonics · 2023Article
- Optical imaging and spectroscopy for the study of the human brain: status report.Neurophotonics · 2022Article
- Effects of changes in end-tidal POPhysiological reports · 2021Article
- Improved accuracy of cerebral blood flow quantification in the presence of systemic physiology cross-talk using multi-layer Monte Carlo modeling.Neurophotonics · 2021Article
- Direct assessment of extracerebral signal contamination on optical measurements of cerebral blood flow, oxygenation, and metabolism.Neurophotonics · 2020Article
- Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Perfusion Enhancement with Respiratory Impedance After Stroke (PERI-Stroke).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- Portable Near-Infrared Technologies and Devices for Noninvasive Assessment of Tissue Hemodynamics.Journal of healthcare engineering · 2019Review
- Cardiovascular magnetic resonance assessment of acute cardiovascular effects of voluntary apnoea in elite divers.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018Article
- Laser safety in fiber-optic monitoring of spinal cord hemodynamics: a preclinical evaluation.Journal of biomedical optics · 2018Article
- Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging.Physiological measurement · 2017Review
- A Model to Simulate Clinically Relevant Hypoxia in Humans.Journal of visualized experiments : JoVE · 2016Article
- Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
STUDY
objectivesChildren with obstructive sleep apnea syndrome (OSAS) often experience periods of hypercapnia during sleep, a potent stimulator of cerebral blood flow (CBF). Considering this hypercapnia exposure during sleep, it is possible that children with OSAS have abnormal CBF responses to hypercapnia even during wakefulness. Therefore, we hypothesized that children with OSAS have blunted CBF response to hypercapnia during wakefulness, compared to snorers and controls.
methodsCBF changes during hypercapnic ventilatory response (HCVR) were tested in children with OSAS, snorers, and healthy controls using diffuse correlation spectroscopy (DCS). Peak CBF changes with respect to pre-hypercapnic baseline were measured for each group. The study was conducted at an academic pediatric sleep center.
resultsTwelve children with OSAS (aged 10.1 ± 2.5 [mean ± standard deviation] y, obstructive apnea hypopnea index [AHI] = 9.4 [5.1-15.4] [median, interquartile range] events/hour), eight snorers (11 ± 3 y, 0.5 [0-1.3] events/hour), and 10 controls (11.4 ± 2.6 y, 0.3 [0.2-0.4] events/hour) were studied. The fractional CBF change during hypercapnia, normalized to the change in end-tidal carbon dioxide, was significantly higher in controls (9 ± 1.8 %/mmHg) compared to OSAS (7.1 ± 1.5, P = 0.023) and snorers (6.7 ± 1.9, P = 0.025).
conclusionsChildren with OSAS and snorers have blunted CBF response to hypercapnia during wakefulness compared to controls. Noninvasive DCS blood flow measurements of hypercapnic reactivity offer insights into physiopathology of OSAS in children, which could lead to further understanding about the central nervous system complications of OSAS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.