Observational studyArthritis care & research2016
Determination of Pain Phenotypes in Knee Osteoarthritis: A Latent Class Analysis Using Data From the Osteoarthritis Initiative.
Observational study in Arthritis care & research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02664896 (Determination of Pain Phenotypes in Older Adults With Knee Osteoarthritis), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determination of Pain Phenotypes in Older Adults With Knee Osteoarthritis
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review of Radiofrequency Ablation for Management of Knee Pain.Current pain and headache reports · 2019Pooled it
- Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature.BMC musculoskeletal disorders · 2016Pooled it
- Stepped care approach for medial tibiofemoral osteoarthritis (STrEAMline): protocol for a randomised controlled trial.BMJ open · 2017Trial
- Advances in heterogeneity and classification of osteoarthritis.Bone research · 2026Review
- Association of baseline MRI-defined structural features with knee symptom trajectories over nine years: Data from the osteoarthritis initiative (OAI).Osteoarthritis imaging · 2026Article
- Racial disparities in pain and total knee arthroplasty across knee osteoarthritis phenotypes.Frontiers in aging · 2026Article
- Association of knee joint performance and gait patterns with pain catastrophizing in patients with severe knee osteoarthritis: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Emerging concepts and challenges in the development of disease-modifying osteoarthritis drugs - a more refined perspective.Archives of pharmacal research · 2025Review
- Association between widespread pain and psychosocial factors in people with knee osteoarthritis: a cross-sectional study of patients from primary care in Denmark.Physiotherapy theory and practice · 2025Article
- Latent class analysis identifies distinct pain phenotypes in newly diagnosed systemic juvenile idiopathic arthritis.Arthritis research & therapy · 2025Article
- Terminologies and definitions used to classify patients with osteoarthritis: a scoping review.BMC rheumatology · 2025Article
- Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain.Osteoarthritis and cartilage · 2024Article
- Does psychological distress predict risk of orthopaedic surgery and postoperative opioid prescribing in patients with hip pain? A retrospective study.BMC musculoskeletal disorders · 2024Article
- Pain-phenotyping in osteoarthritis: Current concepts, evidence, and considerations towards a comprehensive framework for assessment and treatment.Osteoarthritis and cartilage open · 2024Review
- Phenotypes of osteoarthritis-related knee pain and their transition over time: data from the osteoarthritis initiative.BMC musculoskeletal disorders · 2024Article
- Pain-Associated Psychological Distress Is of High Prevalence in Patients With Hip Pain: Characterizing Psychological Distress and Phenotypes.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- Knee osteoarthritis: disease burden, available treatments, and emerging options.Therapeutic advances in musculoskeletal disease · 2024Review
- Prognostic value of illness perception on changes in knee pain among elderly individuals: Two-year results from the Frederiksberg Cohort study.Osteoarthritis and cartilage open · 2023Article
- The Natural History of Knee Osteoarthritis Pain Experience and Risk Profiles.The journal of pain · 2023Observational
- Metabolic and inflammatory profiles define phenotypes with clinical relevance in female knee osteoarthritis patients with joint effusion.Rheumatology (Oxford, England) · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveKnee osteoarthritis (OA) is a broadly applied diagnosis that may describe multiple subtypes of pain. The purpose of this study was to identify phenotypes of knee OA, using measures from the following pain-related domains: 1) knee OA pathology, 2) psychological distress, and 3) altered pain neurophysiology.
methodsData were selected from a total of 3,494 participants at visit 6 of the Osteoarthritis Initiative study. Latent class analysis was applied to the following variables: radiographic OA severity, quadriceps strength, body mass index, the Charlson Comorbidity Index (CCI), the Center for Epidemiologic Studies Depression Scale, the Coping Strategies Questionnaire-Catastrophizing subscale, number of bodily pain sites, and knee joint tenderness at 4 sites. The resulting classes were compared on the following demographic and clinical factors: age, sex, pain severity, disability, walking speed, and use of arthritis-related health care.
resultsA 4-class model was identified. Class 1 (4% of the study population) had higher CCI scores. Class 2 (24%) had higher knee joint sensitivity. Class 3 (10%) had greater psychological distress. Class 4 (62%) had lesser radiographic OA, little psychological involvement, greater strength, and less pain sensitivity. Additionally, class 1 was the oldest, on average. Class 4 was the youngest, had the lowest disability, and least pain. Class 3 had the worst disability and most pain.
conclusionFour distinct pain phenotypes of knee OA were identified. Psychological factors, comorbidity status, and joint sensitivity appear to be important in defining phenotypes of knee OA-related pain.
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