ArticleTissue engineering. Part C, Methods2016
In Vivo Anastomosis and Perfusion of a Three-Dimensionally-Printed Construct Containing Microchannel Networks.
Article in Tissue engineering. Part C, Methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Current trends, applications, and challenges in three-dimensional bioprinting for cardiovascular disease models and therapies.iScience · 2026Review
- Sacrificial Templating for Accelerating Clinical Translation of Engineered Organs.ACS biomaterials science & engineering · 2025Review
- Implantable 3D printed hydrogels with intrinsic channels for liver tissue engineering.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Improving the 3D Printability of Sugar Glass to Engineer Sacrificial Vascular Templates.3D printing and additive manufacturing · 2023Article
- Biodegradable Inks in Indirect Three-Dimensional Bioprinting for Tissue Vascularization.Frontiers in bioengineering and biotechnology · 2022Review
- In Vitro Strategies to Vascularize 3D Physiologically Relevant Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Current Challenges and Solutions to Tissue Engineering of Large-scale Cardiac Constructs.Current cardiology reports · 2021Review
- Bioprinting for the Biologist.Cell · 2021Review
- Blood Flow Within Bioengineered 3D Printed Vascular Constructs Using the Porcine Model.Frontiers in cardiovascular medicine · 2021Article
- Biomaterials for Bioprinting Microvasculature.Chemical reviews · 2020Review
- Bioprinting: From Tissue and Organ Development toChemical reviews · 2020Review
- Microchannel network hydrogel induced ischemic blood perfusion connection.Nature communications · 2020Article
- Bioprinting functional tissues.Acta biomaterialia · 2019Review
- Biofabrication of thick vascularized neo-pedicle flaps for reconstructive surgery.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Tissue Engineering of the Microvasculature.Comprehensive Physiology · 2019Review
- Multiscale bioprinting of vascularized models.Biomaterials · 2019Review
- Engineering Organoid Vascularization.Frontiers in bioengineering and biotechnology · 2019Review
- Sugar glass fugitive ink loaded with calcium chloride for the rapid casting of alginate scaffold designs.Heliyon · 2018Article
- Recent Advances in Extrusion-Based 3D Printing for Biomedical Applications.Advanced healthcare materials · 2018Review
- Microvascular Anastomosis Training in Neurosurgery: A Review.Minimally invasive surgery · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of tissue engineering has advanced the development of increasingly biocompatible materials to mimic the extracellular matrix of vascularized tissue. However, a majority of studies instead rely on a multiday inosculation between engineered vessels and host vasculature rather than the direct connection of engineered microvascular networks with host vasculature. We have previously demonstrated that the rapid casting of three-dimensionally-printed (3D) sacrificial carbohydrate glass is an expeditious and a reliable method of creating scaffolds with 3D microvessel networks. Here, we describe a new surgical technique to directly connect host femoral arteries to patterned microvessel networks. Vessel networks were connected in vivo in a rat femoral artery graft model. We utilized laser Doppler imaging to monitor hind limb ischemia for several hours after implantation and thus measured the vascular patency of implants that were anastomosed to the femoral artery. This study may provide a method to overcome the challenge of rapid oxygen and nutrient delivery to engineered vascularized tissues implanted in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.