ArticleInternational surgery2015
Giant Cholangiolocellular Carcinoma With Early Recurrence That Was Difficult to Distinguish From Cholangiocellular Carcinoma: Report of a Case.
Article in International surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Successfully Treated Case of Cholangiolocellular Carcinoma with a Poor Hepatic Functional Reserve Reporting with Various Imaging Findings.Internal medicine (Tokyo, Japan) · 2021Article
- Locally advanced cholangiolocellular carcinoma successfully treated with curative resection after downsizing chemotherapy: a case report.Surgical case reports · 2021Article
- Application of new ultrasound techniques for focal liver lesions.Journal of medical ultrasonics (2001) · 2020Review
- A case of intrahepatic cholangiocarcinoma that was difficult to diagnose prior to surgery: A case report.Oncology letters · 2019Article
- Intrahepatic Cholangiolocellular and Cholangiocellular Carcinoma - Differences in theInternal medicine (Tokyo, Japan) · 2017Article
- Small cholangiolocellular carcinoma that was difficult to distinguish from cholangiocellular carcinoma: a case report.Surgical case reports · 2017Article
- A case of cholangiolocellular carcinoma featuring intratumoral hepatic artery penetration: A case report.International journal of surgery case reports · 2017Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholangiolocellular carcinoma (CoCC) is a rare type of malignant liver tumor derived from hepatic stem cells, which exist in the canals of Hering. However, the characteristics of CoCC have not been clarified. In general, CoCC is associated with a better prognosis than cholangiocellular carcinoma (CCC). Here, we report a case of giant CoCC, which was difficult to distinguish from CCC and showed early recurrence and necrosis inside the tumor. A 59-year-old man was diagnosed with CCC based on preoperative imaging. The diameter of the tumor was approximately 14 cm, and he subsequently underwent extended right lobectomy of the liver. Histopathologic analysis revealed that tumor cells proliferated and replaced the surrounding normal liver cell cords in front of the tumor. Furthermore, the tumor cells were positive for cytokeratin 19 and epithelial membrane antigen. Epithelial membrane antigen staining pattern was positive on the membranous area of the lumen. Therefore, the tumor was diagnosed as CoCC. Although adjuvant chemotherapy was performed, intrahepatic recurrence occurred at 4 months after surgery. We present here the novel characteristics of CoCC that show early recurrence and necrosis within the tumor. These characteristics have not previously been reported in patients with CoCC.
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