ArticleMolecular ecology2015
Cofeeding intra- and interspecific transmission of an emerging insect-borne rickettsial pathogen.
Article in Molecular ecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Spotted fever group Rickettsia infection kinetics and cutaneous host response during single tick feeding events.PLoS pathogens · 2026Article
- The microbiome of the sucking louse Linognathus stenopsis (Phthiraptera, Anoplura, Linognathiidae).Journal of medical entomology · 2025Article
- Cat Flea Coinfection withVector borne and zoonotic diseases (Larchmont, N.Y.) · 2024Article
- Transposon mutagenesis of Rickettsia felis sca1 confers a distinct phenotype during flea infection.PLoS pathogens · 2022Article
- Pathogen Detection inMicroorganisms · 2022Article
- The role of cofeeding arthropods in the transmission of Rickettsia felis.PLoS neglected tropical diseases · 2022Article
- Article
- Dynamic gene expression in salivary glands of the cat flea during Rickettsia felis infection.Pathogens and disease · 2021Article
- Cat fleas (Current research in parasitology & vector-borne diseases · 2021Article
- Heterogeneity of Orientia tsutsugamushi genotypes in field-collected trombiculid mites from wild-caught small mammals in Thailand.PLoS neglected tropical diseases · 2018Article
- Prevalence and diversity of Rickettsia species in ectoparasites collected from small rodents in Lithuania.Parasites & vectors · 2018Article
- Suspected and Confirmed Vector-Borne Rickettsioses of North America Associated with Human Diseases.Tropical medicine and infectious disease · 2018Review
- Rickettsia felis: A Review of Transmission Mechanisms of an Emerging Pathogen.Tropical medicine and infectious disease · 2017Review
- Spotted fever rickettsiae in wild-living rodents from south-western Poland.Parasites & vectors · 2017Article
- Effect of Rickettsia felis Strain Variation on Infection, Transmission, and Fitness in the Cat Flea (Siphonaptera: Pulicidae).Journal of medical entomology · 2017Article
- Flea-Borne Rickettsioses and Rickettsiae.The American journal of tropical medicine and hygiene · 2017Review
- Extensive genetic diversity of Rickettsiales bacteria in multiple mosquito species.Scientific reports · 2016Article
- Booklice (Liposcelis spp.), Grain Mites (Acarus siro), and Flour Beetles (Tribolium spp.): 'Other Pests' Occasionally Found in Laboratory Animal Facilities.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Detection of vector-borne pathogens in cats and their ectoparasites in southern Italy.Parasites & vectors · 2016Article
- Transmission mechanisms of an emerging insect-borne rickettsial pathogen.Parasites & vectors · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cat fleas (Ctenocephalides felis) are known as the primary vector and reservoir of Rickettsia felis, the causative agent of flea-borne spotted fever; however, field surveys regularly report molecular detection of this infectious agent from other blood-feeding arthropods. The presence of R. felis in additional arthropods may be the result of chance consumption of an infectious bloodmeal, but isolation of viable rickettsiae circulating in the blood of suspected vertebrate reservoirs has not been demonstrated. Successful transmission of pathogens between actively blood-feeding arthropods in the absence of a disseminated vertebrate infection has been verified, referred to as cofeeding transmission. Therefore, the principal route from systemically infected vertebrates to uninfected arthropods may not be applicable to the R. felis transmission cycle. Here, we show both intra- and interspecific transmission of R. felis between cofeeding arthropods on a vertebrate host. Analyses revealed that infected cat fleas transmitted R. felis to naïve cat fleas and rat fleas (Xenopsylla cheopis) via fleabite on a nonrickettsemic vertebrate host. Also, cat fleas infected by cofeeding were infectious to newly emerged uninfected cat fleas in an artificial system. Furthermore, we utilized a stochastic model to demonstrate that cofeeding is sufficient to explain the enzootic spread of R. felis amongst populations of the biological vector. Our results implicate cat fleas in the spread of R. felis amongst different vectors, and the demonstration of cofeeding transmission of R. felis through a vertebrate host represents a novel transmission paradigm for insect-borne Rickettsia and furthers our understanding of this emerging rickettsiosis.
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