Evidence map›Paper›PMID 26414409›Full record

ReviewBiomaterials2015

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels.

Kan Yue, Grissel Trujillo-de Santiago, Mario Moisés Alvarez, Ali Tamayol, Nasim Annabi, Ali Khademhosseini

Abstract readReview
In one paragraph

Review in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,222 papers.

0numbers the graph read from it
0cells of the map it votes in
1,222citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,222 citing papers in PubMed.

  1. Article
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  7. Designing PEDOT:PSS hydrogels for bioelectronic interfaces.Materials today (Kidlington, England) · 2026
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1,162 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kan YueBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA.
Grissel Trujillo-de SantiagoBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Centro de Biotecnología-FEMSA, Tecnológico de Monterrey at Monterrey, Ave. Eugenio Garza Sada 2501 Sur Col. Tecnológico, CP 64849 Monterrey, Nuevo León, Mexico.
Mario Moisés AlvarezBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Centro de Biotecnología-FEMSA, Tecnológico de Monterrey at Monterrey, Ave. Eugenio Garza Sada 2501 Sur Col. Tecnológico, CP 64849 Monterrey, Nuevo León, Mexico.
Ali TamayolBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA.
Nasim AnnabiBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston 02115, MA, USA; Department of Chemical Engineering, Northeastern University, Boston, MA 02115-5000, USA. Electronic address: n.annabi@neu.edu.
Ali KhademhosseiniBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston 02115, MA, USA; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia. Electronic address: alik@rics.bwh.harvard.edu.

Funding

Microengineered Osteons for Bone Tissue EngineeringR01AR057837 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2010 to 2018
$5.1M
3D combinatorial microenvironments for effective cell based therapyR01HL099073 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI, LIAO, RONGLIH · 2010 to 2013
$2.6M
Engineering Vascularized Bone Tissues By Microfabrication And ScaffoldingR01DE021468 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2011 to 2014
$1.8M
A Microfabrication Platform for Direct Printing Vascularized Functional Tissue CoR01EB012597 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2010 to 2013
$1.4M
Microengineered Osteoinductive and Vasculogenic ScaffoldR56AR063745 · NIAMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI JABBARI, ESMAIEL · 2013 to 2014
$669k
A miniaturized model of human skin and lymph node for drug discovery and testingR56AI105024 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2014 to 2014
$442k
Angiogenic Biomaterials as Dermal Scaffolds to Enhance Diabetic Wound HealingR21AR068258 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2015 to 2016
$412k
NHLBI NIH HHS HL099073NHLBI NIH HHS R01 HL099073NIAID NIH HHS AI105024NIAID NIH HHS R56 AI105024NIAMS NIH HHS AR057837NIAMS NIH HHS AR063745NIAMS NIH HHS R01 AR057837NIAMS NIH HHS R21 AR068258NIAMS NIH HHS R56 AR063745NIBIB NIH HHS EB012597NIBIB NIH HHS R01 EB012597NIDCR NIH HHS DE021468NIDCR NIH HHS R01 DE021468
6 · The paper itself

Abstract

Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of tissue engineering applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental cell research, cell signaling, drug and gene delivery, and bio-sensing.

Indexed as

Amino Acid MotifsAnimalsBiocompatible MaterialsCell ProliferationExtracellular MatrixGelatinGraphiteHumansHydrogelsMethacrylatesMiceMicrofluidicsNanotubes, CarbonOxidesPolymersTissue EngineeringBiocompatible MaterialsGelatinGraphiteHydrogelsMethacrylatesNanotubes, CarbonOxidesPolymersBiomedicalGelatinGelMAHydrogelMethacryloylTissue engineering

Identifiers

PMID26414409
PMCPMC4610009

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.