ArticlePloS one2015
Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 62 citations in OpenAlex.
- The Collaborative Collapse: Bile Acid Dysmetabolism as a Central Pathogenic Driver in Canine and Feline Multi-Systemic Disorders-From Mechanisms to Precision Therapeutics.Veterinary sciences · 2026Review
- Nutritional Factors Related to Canine Gallbladder Diseases-A Scoping Review.Veterinary sciences · 2024Review
- Acquired dysfunction of CFTR underlies cystic fibrosis-like disease of the canine gallbladder.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Article
- Increased lipogenesis and lipidosis of gallbladder epithelium in dogs with gallbladder mucocele formation.PloS one · 2024Article
- Article
- MUC5AC and MUC5B expression in canine gallbladder mucocele epithelial cells.The Journal of veterinary medical science · 2023Article
- Canine Gallbladder Erosion/Ulcer and Hemocholecyst: Clinicopathological Characteristics of 14 Cases.Animals : an open access journal from MDPI · 2023Article
- Vaping additives cannabinoid oil and vitamin E acetate adhere to and damage the human airway epithelium.Journal of applied toxicology : JAT · 2023Article
- Article
- Effects of proportions of carbohydrates and fats in diets on mucin concentration and bile composition in gallbladder of dogs.The Journal of veterinary medical science · 2022Article
- Long-Term Outcome after Cholecystectomy without Common Bile Duct Catheterization and Flushing in Dogs.Animals : an open access journal from MDPI · 2022Article
- A multicenter retrospective study assessing progression of biliary sludge in dogs using ultrasonography.Journal of veterinary internal medicine · 2022Article
- Ultrasonographic patterns, clinical findings, and prognostic variables in dogs from Asia with gallbladder mucocele.Journal of veterinary internal medicine · 2022Article
- Culture with apically applied healthy or disease sputum alters the airway surface liquid proteome and ion transport across human bronchial epithelial cells.American journal of physiology. Cell physiology · 2021Article
- Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver.Animals : an open access journal from MDPI · 2021Article
- Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study.Journal of veterinary internal medicine · 2021Article
- Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Human Fallopian Tube Epithelial Cell Culture Model To Study Host Responses to Chlamydia trachomatis Infection.Infection and immunity · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Mucosal protection of the gallbladder is vital yet we know very little about the mechanisms involved. In domestic dogs, an emergent syndrome referred to as gallbladder mucocele formation is characterized by excessive secretion of abnormal mucus that results in obstruction and rupture of the gallbladder. The cause of gallbladder mucocele formation is unknown. In these first mechanistic studies of this disease, we investigated normal and mucocele-forming dog gallbladders to determine the source, identity, biophysical properties, and protein associates of the culprit mucins with aim to identify causes for abnormal mucus behavior. We established that mucocele formation involves an adoptive excess secretion of gel forming mucins with abnormal properties by the gallbladder epithelium. The mucus is characterized by a disproportionally significant increase in Muc5ac relative to Muc5b, defective mucin un-packaging, and mucin-interacting innate defense proteins that are capable of dramatically altering the physical and functional properties of mucus. These findings provide an explanation for abnormal mucus behavior and based on similarity to mucus observed in the airways of people with cystic fibrosis, suggest that abnormal mechanisms for maintenance of gallbladder epithelial hydration may be an instigating factor for mucocele formation in dogs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.