Evidence map›Paper›PMID 26414065›Full record

Observational studyAIDS research and human retroviruses2016

Late Presentation into Care of HIV Disease and Its Associated Factors in Asia: Results of TAHOD.

Su Jin Jeong, Claire Italiano, Romanee Chaiwarith, Oon Tek Ng, Sasheela Vanar, Awachana Jiamsakul, Vonthanak Saphonn, Kinh Van Nguyen, Sasisopin Kiertiburanakul, Man Po Lee and 16 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in AIDS research and human retroviruses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 20 institutions in 11 countries.

Su Jin Jeong1 Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine , Seoul, Korea.
Claire Italiano2 University of Malaya Medical Centre , Kuala Lumpur, Malaysia .
Romanee Chaiwarith3 Research Institute for Health Sciences, Chiang Mai University , Chiang Mai, Thailand .
Oon Tek Ng4 Department of Infectious Diseases, Tan Tock Seng Hospital , Singapore, Singapore .
Sasheela Vanar2 University of Malaya Medical Centre , Kuala Lumpur, Malaysia .
Awachana Jiamsakul5 The Kirby Institute , UNSW Australia, Sydney, Australia .
Vonthanak Saphonn6 National Center for HIV/AIDS, Dermatology & STDs, and University of Health Sciences , Phnom Penh, Cambodia .
Kinh Van Nguyen7 National Hospital for Tropical Diseases , Hanoi, Vietnam .
Sasisopin Kiertiburanakul8 Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand .
Man Po Lee9 Queen Elizabeth Hospital , Hong Kong, China .
Tuti Parwati Merati10 Faculty of Medicine Udayana University and Sanglah Hospital , Bali, Indonesia .
Thuy Thanh Pham11 Bach Mai Hospital , Hanoi, Vietnam .
Evy Yunihastuti12 Working Group on AIDS Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital , Jakarta, Indonesia .
Rossana Ditangco13 Research Institute for Tropical Medicine , Manila, Philippines .
Nagalingeswaran Kumarasamy14 YRGCARE Medical Centre, VHS , Chennai, India .
Fujie Zhang15 Beijing Ditan Hospital, Capital Medical University , Beijing, China .
Wingwai Wong16 Taipei Veterans General Hospital , Taipei, Taiwan .
Benedict L H Sim17 Hospital Sungai Buloh , Sungai Buloh, Malaysia .
Sanjay Pujari18 Institute of Infectious Diseases , Pune, India .
Pacharee Kantipong19 Chiangrai Prachanukroh Hospital , Chiang Rai, Thailand .
Praphan Phanuphak20 HIV-NAT/Thai Red Cross AIDS Research Centre , Bangkok, Thailand .
Winai Ratanasuwan21 Faculty of Medicine, Siriraj Hospital, Mahidol University , Bangkok, Thailand .
Shinichi Oka22 National Center for Global Health and Medicine , Tokyo, Japan .
Mahiran Mustafa23 Hospital Raja Perempuan Zainab II , Kota Bharu, Malaysia .
Nicolas Durier24 TREAT Asia, amfAR-The Foundation for AIDS Research , Bangkok, Thailand .
Jun Yong Choi1 Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine , Seoul, Korea.
University Malaya Medical Centre · MYYonsei University · KRBạch Mai Hospital · VNCapital Medical University · CNChiang Mai University · THChiangRai Prachanukroh Hospital · THHIV Netherlands Australia Thailand Research Collaboration · THHospital for Tropical Diseases · VNHospital Raja Perempuan Zainab II · MYHospital Sungai Buloh · MYMahidol University · THNational Center for Global Health and Medicine · JPQueen Elizabeth Hospital · CNRamathibodi Hospital · THResearch Institute for Tropical Medicine · PHRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo · IDTaipei Veterans General Hospital · TWTan Tock Seng Hospital · SGUdayana University · IDYR Gaitonde Centre for AIDS Research and Education · IN

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
NIAID NIH HHS U01 AI069907
6 · The paper itself

Abstract

Many HIV-infected individuals do not enter health care until late in the infection course. Despite encouraging earlier testing, this situation has continued for several years. We investigated the prevalence of late presenters and factors associated with late presentation among HIV-infected patients in an Asian regional cohort. This cohort study included HIV-infected patients with their first positive HIV test during 2003-2012 and CD4 count and clinical status data within 3 months of that test. Factors associated with late presentation into care (CD4 count <200 cells/μl or an AIDS-defining event within ±3 months of first positive HIV test) were analyzed in a random effects logistic regression model. Among 3,744 patients, 2,681 (72%) were late presenters. In the multivariable model, older patients were more likely to be late presenters than younger (≤30 years) patients [31-40, 41-50, and ≥51 years: odds ratio (OR) = 1.57, 95% confidence interval (CI) 1.31-1.88; OR = 2.01, 95% CI 1.58-2.56; and OR = 1.69, 95% CI 1.23-2.31, respectively; all p ≤ 0.001]. Injecting drug users (IDU) were more likely (OR = 2.15, 95% CI 1.42-3.27, p < 0.001) and those with homosexual HIV exposure were less likely (OR = 0.45, 95% CI 0.35-0.58, p < 0.001) to be late presenters compared to those with heterosexual HIV exposure. Females were less likely to be late presenters (OR = 0.44, 95% CI 0.36-0.53, p < 0.001). The year of first positive HIV test was not associated with late presentation. Efforts to reduce the patients who first seek HIV care at the late stage are needed. The identified risk factors associated with late presentation should be utilized in formulating targeted public health intervention to improve earlier entry into HIV care.

Indexed as

Delayed DiagnosisAdultAge FactorsAsiaCD4 Lymphocyte CountFemaleHIV InfectionsHumansMaleMiddle AgedPrevalenceProspective StudiesSex FactorsSexual BehaviorSubstance Abuse, Intravenous

Identifiers

PMID26414065
PMCPMC4779961
OpenAlexW1909607737

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.