Evidence map›Paper›PMID 26414054›Full record

ArticleAcademic medicine : journal of the Association of American Medical Colleges2015

Sustaining the Clinical and Translational Research Workforce: Training and Empowering the Next Generation of Investigators.

Helen L Yin, Janice Gabrilove, Rebecca Jackson, Carol Sweeney, Alecia M Fair, Robert Toto, Clinical and Translational Science Award “Mentored to Independent Investigator Working Group Committee

Abstract read
In one paragraph

Article in Academic medicine : journal of the Association of American Medical Colleges, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Advanced Research Institute Scholars' Perspectives on Program Success: A Self-determination Theory Evaluation.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Article
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  6. The development, validity, and reliability of the Researcher Investment Tool.Journal of clinical and translational science · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Journal of clinical and translational science · 2024
    Article
  12. Article
  13. Article
  14. Advanced Research Institute (ARI): Supporting the Geriatric Mental Health Research Pipeline.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Article
  15. The national institute on drug abuse diversity scholars network: success for a diverse addiction science workforce.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Helen L YinH.L. Yin is professor of physiology, codirector, Education Career Development Program, Center for Translational Medicine, and associate dean, Office of Women's Careers, University of Texas Southwestern Medical Center, Dallas, Texas. J. Gabrilove is professor of medicine and oncological services, director, Hematology-Oncology Fellowship Program, director, Clinical Research Education Programs, and codirector, KL2 Scholars and MD/MSCR Programs, Icahn School of Medicine at Mount Sinai, New York, New York. R. Jackson is professor of medicine, associate dean for clinical research, and director, Center for Clinical and Translational Science, Ohio State University, Columbus, Ohio. C. Sweeney is associate professor of internal medicine and codirector, Research Education, Training, and Career Development, Utah Center for Clinical and Translational Science, University of Utah School of Medicine, Salt Lake City, Utah. A.M. Fair is research services consultant II, Vanderbilt Institute for Clinical Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee. R. Toto is professor of internal medicine, codirector, Education Career Development Program, and principal investigator, Clinical Translational Science Award, Center for Translational Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Janice Gabrilove
Rebecca Jackson
Carol Sweeney
Alecia M Fair
Robert Toto
Clinical and Translational Science Award “Mentored to Independent Investigator Working Group Committee

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
Mount Sinai Institutes for Clinical and Translational SciencesUL1TR000067 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SAMPSON, HUGH A · 2012 to 2014
$16.5M
The Ohio State University Center for Clinical and Translational Science (UL1)UL1TR000090 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2012 to 2013
$7.9M
UT-Southwestern Clinical and Translational Alliance for Research (UT-STAR) (TL1)UL1TR000451 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2012 to 2012
$6.3M
University of Utah Center for Clinical and Translational Science-UL1UL1TR000105 · NCATS · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2012 to 2013
$5.1M
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1KL2TR001103 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$4.0M
Conduits: MSHS Translational Science HubTL1TR001434 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GABRILOVE, JANICE L · 2015 to 2019
$2.1M
NCATS NIH HHS 2UL1TR000445NCATS NIH HHS 8UL1TR000105NCATS NIH HHS KL2 TR001103NCATS NIH HHS TL1 TR001434NCATS NIH HHS UL1 TR000067NCATS NIH HHS UL1TR000067NCATS NIH HHS UL1 TR000090NCATS NIH HHS UL1TR000090NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR000451NCATS NIH HHS UL1 TR001105NCATS NIH HHS UL1TR001105
6 · The paper itself

Abstract

There is mounting concern that clinician-scientists are a vanishing species and that the pipeline for clinical and translational research (CTR) investigators is in jeopardy. For the majority of current junior CTR investigators, the career path involves first obtaining a National Institutes of Health (NIH)-funded K-type career development award, particularly K08 and K23, and subsequently an NIH R01. This transition, popularly referred to as K2R, is a major hurdle with a low success rate and gaps in funding. In this Perspective, the authors identify factors that facilitate K2R transition and important aspects of increasing and sustaining the pipeline of CTR investigators. They also highlight significant differences in success rates of women and those underrepresented in biomedical research. Early career exposure to research methodology, protected time, multidisciplinary mentoring, and institutional "culture shift" are important for fostering and rewarding team science. Mentoring is the single most important contributor to K2R success, and emerging evidence suggests that formal mentor training and team mentoring are effective. Leadership training can empower junior investigators to thrive as independent CTR investigators. Future research should focus on delineating the difference between essential and supplemental factors to achieve this transition, and mentoring methods that foster success, including those that promote K2R transition of women and those underrepresented in biomedical research. The Clinical and Translational Science Awards National Consortium is well positioned to test existing models aimed at shortening the time frame, increasing the rate of K2R transition, and identifying strategies that improve success.

Indexed as

Biomedical ResearchCareer MobilityFemaleHumansLeadershipMaleMentorsNational Institutes of Health (U.S.)Research PersonnelResearch Support as TopicSex FactorsTranslational Research, BiomedicalUnited StatesWorkforce

Identifiers

PMID26414054
PMCPMC4587496

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.