ArticlePloS one2015
Colon Necrosis Due to Sodium Polystyrene Sulfonate with and without Sorbitol: An Experimental Study in Rats.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Histopathological lesions of the gastrointestinal tract associated with the use of polystyrene sulfonate and sevelamer: a meta-analysis.Pathologica · 2024Pooled it
- [Kalimate-Associated Gastric Ulcer].The Korean journal of helicobacter and upper gastrointestinal research · 2024Article
- Semaglutide and Patients Receiving Hemodialysis: Case Reports of Unexpected Benefits for Hyperphosphatemia and Hyperkalemia.The Canadian journal of hospital pharmacy · 2024Article
- Sodium-Polystyrene Sulfonate-Induced Colitis.GE Portuguese journal of gastroenterology · 2023Article
- Adverse Gastrointestinal Events With Sodium Polystyrene Sulfonate Use in Patients on Maintenance Hemodialysis: An International Cohort Study.Canadian journal of kidney health and disease · 2023Article
- Adverse Gastrointestinal Effects with Kayexalate or Kalimate: A Comprehensive Review.Clinical and experimental gastroenterology · 2021Review
- Kayexalate-induced colitis and rectal stricture.BMJ case reports · 2020Article
- Initiation of sodium polystyrene sulphonate and the risk of gastrointestinal adverse events in advanced chronic kidney disease: a nationwide study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Observational
- Intestinal necrosis after co-administration of sodium polystyrene sulfonate and activated charcoal.Clinical case reports · 2020Article
- Polysulfonate Resins in Hyperkalemia: A Systematic Review.Canadian journal of kidney health and disease · 2020Article
- Hepatic portal venous gas due to polystyrene sulfonate-induced enteritis.Clinical journal of gastroenterology · 2018Article
- Sodium polystyrene sulfonate crystals in the gastric wall of a patient with upper gastrointestinal bleeding and gastric perforation: an incidental finding or a pathogenic factor?Journal of surgical case reports · 2018Article
- Treatment of Severe Hyperkalemia: Confronting 4 Fallacies.Kidney international reports · 2018Review
- Treatment of Hyperkalemia in Heart Failure.Current heart failure reports · 2017Review
- The role of cation-exchange resins in hyperkalemia management.Medical journal, Armed Forces IndiaReview
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBased on a single rat study by Lillemoe et al, the consensus has been formed to implicate sorbitol rather than sodium polystyrene sulfonate (SPS) as the culprit for colon necrosis in humans treated with SPS and sorbitol. We tested the hypothesis that colon necrosis by sorbitol in the experiment was due to the high osmolality and volume of sorbitol rather than its chemical nature.
methods26 rats underwent 5/6 nephrectomy. They were divided into 6 groups and given enema solutions under anesthesia (normal saline, 33% sorbitol, 33% mannitol, SPS in 33% sorbitol, SPS in normal saline, and SPS in distilled water). They were sacrificed after 48 hours of enema administration or earlier if they were very sick. The gross appearance of the colon was visually inspected, and then sliced colon tissues were examined under light microscopy.
results1 rat from the sorbitol and 1 from the mannitol group had foci of ischemic colonic changes. The rats receiving SPS enema, in sorbitol, normal saline, distilled water, had crystal deposition with colonic necrosis and mucosal erosion. All the rats not given SPS survived until sacrificed at 48 h whereas 11 of 13 rats that received SPS in sorbitol, normal saline or distilled water died or were clearly dying and sacrificed sooner. There was no difference between sorbitol and mannitol when given without SPS.
conclusionsIn a surgical uremic rat model, SPS enema given alone or with sorbitol or mannitol seemed to cause colon necrosis and high mortality rate, whereas 33% sorbitol without SPS did not.
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