Evidence map›Paper›PMID 26413556›Full record

ArticleNeurogenesis (Austin, Tex.)2014

Axons take a dive: Specialized contacts of serotonergic axons with cells in the walls of the lateral ventricles in mice and humans.

Cheuk Ka Tong, Arantxa Cebrián-Silla, Mercedes F Paredes, Eric J Huang, Jose Manuel García-Verdugo, Arturo Alvarez-Buylla

Abstract read
In one paragraph

Article in Neurogenesis (Austin, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cheuk Ka TongDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research; University of California San Francisco; San Francisco, CA USA ; Neuroscience Graduate Program; University of California San Francisco; San Francisco, CA USA.
Arantxa Cebrián-SillaLaboratory of Comparative Neurobiology; Instituto Cavanilles; Universidad de Valencia; CIBER NED; Valencia, Spain.
Mercedes F ParedesDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research; University of California San Francisco; San Francisco, CA USA ; Department of Neurology; University of California San Francisco; San Francisco, CA USA.
Eric J HuangNeuroscience Graduate Program; University of California San Francisco; San Francisco, CA USA ; Department of Pathology; University of California San Francisco; San Francisco, CA USA.
Jose Manuel García-VerdugoLaboratory of Comparative Neurobiology; Instituto Cavanilles; Universidad de Valencia; CIBER NED; Valencia, Spain ; Unidad Mixta de Esclerosis Múltiple y Neurorregeneración; II S Hospital La Fe; Valencia, Spain.
Arturo Alvarez-BuyllaDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research; University of California San Francisco; San Francisco, CA USA ; Neuroscience Graduate Program; University of California San Francisco; San Francisco, CA USA.

Funding

NEUROGENESIS IN THE ADULT VERTEBRATE BRAINR01NS028478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 1996 to 2024
$8.6M
Heterogeneity of Adult Neural Stem CellsR37HD032116 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 2008 to 2017
$4.7M
CHARACTERIZATION OF NEURAL STEM CELLS IN THE ADULT BRAINR37NS028478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 2000 to 2007
$2.9M
POSTNATAL NEURONAL PRECURSORS AND BRAIN REPAIRR01HD032116 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 1994 to 2007
$1.7M
NICHD NIH HHS R01 HD032116NICHD NIH HHS R37 HD032116NINDS NIH HHS R01 NS028478NINDS NIH HHS R37 NS028478
6 · The paper itself

Abstract

In the walls of the lateral ventricles of the adult mammalian brain, neural stem cells (NSCs) and ependymal (E1) cells share the apical surface of the ventricular-subventricular zone (V-SVZ). In a recent article, we show that supraependymal serotonergic (5HT) axons originating from the raphe nuclei in mice form an extensive plexus on the walls of the lateral ventricles where they contact E1 cells and NSCs. Here we further characterize the contacts between 5HT supraependymal axons and E1 cells in mice, and show that suprependymal axons tightly associated to E1 cells are also present in the walls of the human lateral ventricles. These observations raise interesting questions about the function of supraependymal axons in the regulation of E1 cells.

Indexed as

adult neurogenesisependymal cellshumanneural stem cellsserotoninsupraependymal axons

Identifiers

PMID26413556
PMCPMC4583132

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.